A new mutant mouse model lacking mitochondrial-associated CB1 receptor

Antonio C. Pagano Zottola, Edgar Soria-Gomez, Itziar Bonilla-del-Río, Carolina Muguruza, Geoffrey Terral, Laurie M. Robin, José F. Oliveira da Cruz, Bastien Redon, Thierry Lesté-Lasserre, Tarson Tolentino-Cortes, Nagore Puente, Gabriel Barreda-Gómez, Francis Chaouloff, Luis F. Callado, Pedro Grandes, Giovanni Marsicano, Luigi Bellocchio
Preprint bioRxiv. 2020-03-31; :
DOI: 10.1101/2020.03.30.009472

The idea that the effects of drugs largely depend on subcellular target location is emerging as a novel predictive factor of their beneficial or adverse outcomes. G protein-coupled type-1 cannabinoid receptors (CB1) are regulators of several brain functions as well as the main targets of cannabinoid-based medicines.Besides their classical location at plasma membranes, CB1 receptors are present at different locations within cells, including in association to mitochondrial membranes (mtCB1). Here we report the generation and characterization of a mutant mouse line, which lack mtCB1 receptors.

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