[A new chapter in the field of memory: hippocampal neo-neurogenesis].

1. Biol Aujourdhui. 2010;204(2):113-29. doi: 10.1051/jbio/2010004. Epub 2010 Jun 21.

[A new chapter in the field of memory: hippocampal neo-neurogenesis].

[Article in French]

Dupret D(1), Abrous DN.

Author information:
(1)MRC Anatomical Neuropharmacology Unit, Oxford OX1 3TH, UK.

The dogma according to which “once the development of the central nervous system
ended, generation of neurons was impossible” has been challenged by the discovery
that new neurons are created in specific regions of the adult mammalian brain.
This discovery has been one of the most controversial of modern neuroscience. One
of these regions is the dentate gyrus of the hippocampal formation, a key
structure in memory. Here we will review our current knowledge on the role of
adult hippocampal neurogenesis in memory and in the pathophysiology of memory. In
particular we will review evidence showing that adult-born neurons are required
for learning and memory and that an alteration of their production rate leads to
memory impairments. We also discuss how neurogenesis is finely shaped by learning
for the purpose of mnemonic information processing.

© Société de Biologie, 2010.

DOI: 10.1051/jbio/2010004
PMID: 20950556 [Indexed for MEDLINE]

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