A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
Addiction Biology. 2010-11-29; 16(1): 120-123
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1. Addict Biol. 2011 Jan;16(1):120-3. doi: 10.1111/j.1369-1600.2010.00232.x.
A decrease in gamma-synuclein expression within the nucleus accumbens increases
cocaine intravenous self-administration in the rat.
Boyer F(1), Balado E, Piazza PV, Dreyer JL, Deroche-Gamonet V.
(1)Institute of Biochemistry, University of Fribourg, Switzerland.
Except as a marker of cancer progression, gamma-synuclein (GSyn) had received
little attention. Recent data showed however that GSyn modulates cocaine-induced
locomotor effects, suggesting that it could also play a role in cocaine
reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected
in the nucleus accumbens and cocaine reinforcing effects were evaluated by means
of intravenous self-administration. A dose-response curve was followed by
procedures of progressive ratio, extinction, cocaine- and cue-induced
reinstatements. Decrease of GSyn expression increased self-administration over a
large range of doses. This effect was associated with an increase in
cocaine-induced reinstatement. The present data reveal that GSyn exert a specific
negative control on cocaine-induced reinforcing and incentive effects.
© 2010 The Authors. Addiction Biology © 2010 Society for the Study of Addiction.
PMID: 20579003 [Indexed for MEDLINE]