A comparison between the full diallel cross and the simplified triple-test cross
Theoret. Appl. Genetics. 1986-11-01; 73(1): 27-30
Read on PubMed
1. Theor Appl Genet. 1986 Nov;73(1):27-30. doi: 10.1007/BF00273714.
A comparison between the full diallel cross and the simplified triple-test cross.
Crusio WE(1), van Abeelen JH.
(1)Department of Zoology, University of Nijmegen, Toernooiveld, NL-6525, ED
Nijmegen, The Netherlands.
The simplified triple-test cross (sTTC) is a mating design that, because of its
economic use of the experimental material as compared with other designs, seems
very attractive. In theory, its power is almost equal to that of more elaborate
designs such as the diallel cross. To evaluate the merits of both designs in a
genetic analysis of mouse behavior, the results of a previous replicated 4×4
diallel cross (Crusio and van Abeelen 1986) were reanalyzed as a sTTC. We found
that, at least with the fairly low number of strains employed, the sTTC analysis
is clearly inferior to the diallel cross. This finding, in combination with some
theoretical considerations, leads to the conclusion that the sTTC design is not a
very useful one for such studies.