4-Hz oscillations synchronize prefrontal–amygdala circuits during fear behavior

Nikolaos Karalis, Cyril Dejean, Fabrice Chaudun, Suzana Khoder, Robert R Rozeske, Hélène Wurtz, Sophie Bagur, Karim Benchenane, Anton Sirota, Julien Courtin, Cyril Herry
Nat Neurosci. 2016-02-15; 19(4): 605-612
DOI: 10.1038/nn.4251

PubMed
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1. Nat Neurosci. 2016 Apr;19(4):605-12. doi: 10.1038/nn.4251. Epub 2016 Feb 15.

4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

Karalis N(1)(2)(3), Dejean C(1)(2), Chaudun F(1)(2), Khoder S(1)(2), Rozeske
RR(1)(2), Wurtz H(1)(2), Bagur S(4), Benchenane K(4), Sirota A(3), Courtin
J(1)(2)(5), Herry C(1)(2).

Author information:
(1)INSERM, Neurocentre Magendie, U862, Bordeaux, France.
(2)Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
(3)Bernstein Center for Computational Neuroscience Munich, Munich Cluster of
Systems Neurology (SyNergy), Faculty of Medicine, Ludwig-Maximilians Universität
München, Planegg-Martinsried, Germany.
(4)Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS
UMR 8249, ESPCI ParisTech, Ecole Supérieure de Physique et de Chimie
Industrielles de la Ville de Paris, Paris, France.
(5)Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Fear expression relies on the coordinated activity of prefrontal and amygdala
circuits, yet the mechanisms allowing long-range network synchronization during
fear remain unknown. Using a combination of extracellular recordings,
pharmacological and optogenetic manipulations, we found that freezing, a
behavioral expression of fear, temporally coincided with the development of
sustained, internally generated 4-Hz oscillations in prefrontal-amygdala
circuits. 4-Hz oscillations predict freezing onset and offset and synchronize
prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz
oscillations coordinates prefrontal-amygdala activity and elicits fear behavior.
These results unravel a sustained oscillatory mechanism mediating
prefrontal-amygdala coupling during fear behavior.

DOI: 10.1038/nn.4251
PMCID: PMC4843971
PMID: 26878674 [Indexed for MEDLINE]


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