What influences preneoplastic colorectal lesion recurrence?
Oncotarget. 2016-11-25; 8(7): 12406-12416
DOI: 10.18632/oncotarget.13628
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1. Oncotarget. 2017 Feb 14;8(7):12406-12416. doi: 10.18632/oncotarget.13628.
What influences preneoplastic colorectal lesion recurrence?
De Maio G(1), Zama E(1), Rengucci C(1), Calistri D(1).
Author information:
(1)Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura
dei Tumori (IRST) IRCCS, Meldola (FC), Italy.
The hypothesis of the local recurrence of preneoplastic lesions was first put
forward in the 1950s. Disease recurrence may result from an inherent imbalance in
cell proliferation that promotes carcinogenesis in apparently normal mucosa. Our
review sheds light on how early preneoplastic lesions could be used to diagnose
relapsed preneoplastic and, developing neoplastic lesions. We focus in detail on
the clinical-pathological and molecular features of adenoma subtypes and their
role in relapsed adenoma and their development into colorectal carcinoma.
Moreover, we include the data available on microbiota and its metabolites and
their role in recurrence. We strongly believe that a significant improvement
could be achieved in colorectal screening by introducing personalized endoscopic
surveillance for polyp-bearing patients on the basis of the presence of molecular
markers that are predictive of recurrence.
DOI: 10.18632/oncotarget.13628
PMCID: PMC5355354
PMID: 27902488 [Indexed for MEDLINE]