X-linked mental retardation: focus on synaptic function and plasticity
Journal of Neurochemistry. 2009-04-01; 109(1): 1-14
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1. J Neurochem. 2009 Apr;109(1):1-14. doi: 10.1111/j.1471-4159.2009.05881.x. Epub
2009 Jan 13.
X-linked mental retardation: focus on synaptic function and plasticity.
Humeau Y(1), Gambino F, Chelly J, Vitale N.
(1)Département Neurotransmission et Sécrétion Neuroendocrine, Institut des
Neurosciences Cellulaires et Intégratives, UPR-3212, CNRS and Université de
Strasbourg, Strasbourg, France.
Among mental disorders, mental retardation has been shown to be caused by various
factors including a large array of genetic mutations. On the basis of remarkable
progress, the emerging view is that defects in the regulation of synaptic
activity and morphogenesis of dendritic spines are apparently common features
associated with mutations in several genes implicated in mental retardation. In
this review, we will discuss X-linked MR-related gene products that are
potentially involved in the normal structure and function of the synapses, with a
particular focus on pre- and/or post-synaptic plasticity mechanisms. Progress in
understanding the underlying conditions leading to mental retardation will
undoubtedly be gained from a closer collaboration of geneticists, physiologists
and cognitive neuroscientists, which should enable the establishment of
PMID: 19183273 [Indexed for MEDLINE]