Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Sci. Transl. Med.. 2021-09-15; 13(611):
DOI: 10.1126/scitranslmed.abe8455
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Delpech JC(1)(2), Pathak D(3), Varghese M(4), Kalavai SV(1), Hays EC(3), Hof PR(4), Johnson WE(5), Ikezu S(1), Medalla M(3)(6), Luebke JI(3)(6), Ikezu T(1)(6)(7).
Author information:
(1)Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
(2)University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux, France.
(3)Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
(4)Nash Family Department of Neuroscience, Friedman Brain Institute, and Ronald C. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
(5)Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
(6)Center for Systems Neuroscience, Boston University, Boston, MA, USA.
(7)Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.