Which psychiatric comorbidities in cannabis dependence during adolescence? Comparison of outpatients and controls,Quelles comorbidités psychiatriques dans la dépendance au cannabis à l’adolescence ? Comparaison de patients consultants et de témoins
L'Encéphale. 2018-02-01; 44(1): 2-8
DOI: 10.1016/j.encep.2016.05.013
Lire sur PubMed
1. Encephale. 2018 Feb;44(1):2-8. doi: 10.1016/j.encep.2016.05.013. Epub 2016 Sep
13.
[Which psychiatric comorbidities in cannabis dependence during adolescence?
Comparison of outpatients and controls].
[Article in French]
Dorard G(1), Bungener C(2), Phan O(3), Edel Y(4), Corcos M(5), Berthoz S(6).
Author information:
(1)Laboratoire de psychopathologie et processus de santé (EA 4057), institut
Henri-Piéron, IUPDP, université Paris Descartes-Sorbonne Paris Cité, 71, avenue
Édouard-Vaillant, 92100 Boulogne-Billancourt, France. Electronic address:
.
(2)Laboratoire de psychopathologie et processus de santé (EA 4057), institut
Henri-Piéron, IUPDP, université Paris Descartes-Sorbonne Paris Cité, 71, avenue
Édouard-Vaillant, 92100 Boulogne-Billancourt, France.
(3)Clinique Dupré, FSEF, Sceaux, CJC Pierre-Nicole, Croix-Rouge française, 92330
Sceaux, France; CESP, Inserm U1178, université Paris Sud, Cochin, maison des
Adolescents, 75005 Paris, France.
(4)Centre de référence en addictologie, hôpital universitaire de la
Pitié-Salpêtrière, 75014 Paris, France.
(5)Département de psychiatrie de l’adolescent et du jeune adulte, institut
mutualiste Montsouris, 75014 Paris, France.
(6)CESP, Inserm U1178, université Paris Sud, Cochin, maison des Adolescents,
75005 Paris, France; Département de psychiatrie de l’adolescent et du jeune
adulte, institut mutualiste Montsouris, 75014 Paris, France.
BACKGROUND: The use of illicit substances, in particular cannabis, among French
adolescents and young adults has become an important public health concern. A
better understanding of the mechanisms involved in pathological substance use is
nowadays critical. Psychiatric comorbidities have been previously reported in
adult substance abusers but are less documented in adolescents, especially
regarding cannabis dependence.
OBJECTIVES: We investigated mental health problems in adolescents and young
adults, seeking treatment for their problematic cannabis use, comparatively to
healthy controls, taking into account the participant’s gender and age.
Moreover, we explored the relationships between psychiatric diagnosis and
substance use modalities.
METHODS: In total, 100 young patients (80 males – mean age 18.2 (SD=2.9; [14 to
25] years old)) with a cannabis dependence (DSM-IV-TR criteria) seeking
treatment in an addiction unit, and 82 healthy control subjects (50 males – mean
age 18.3 (SD=3.4; [14 to 25] years old)) with no substance misuse diagnostic
other than for alcohol, participated in the study. The MINI was administered to
evaluate cannabis dependence, and DSM-IV axis I comorbid diagnosis, and a
semi-structured interview was used to determine psychoactive substance use.
RESULTS: Statistical analyses revealed that 79 % of the patients reported at
least one other non-drug or alcohol comorbid diagnosis, versus 30.5 % in the
control group (χ2=16.83; P