Voluntary physical activity improves spatial and recognition memory deficits induced by post-weaning chronic exposure to a high-fat diet
Physiology & Behavior. 2022-10-01; 254: 113910
DOI: 10.1016/j.physbeh.2022.113910
Lire sur PubMed
Hernández-Ramírez S(1), Salcedo-Tello P(2), Osorio-Gómez D(3), Bermúdez-Rattoni F(3), Pacheco-López G(2), Ferreira G(4), Lafenetre P(5), Guzmán-Ramos KR(6); OBETEEN Consortium.
Author information:
(1)Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma
Metropolitana (UAM), Av. de las Garzas No. 10, Lerma de Villada, Estado de
México, C.P. 52005, Mexico.
(2)Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la
Salud. Universidad Autónoma Metropolitana (UAM), Unidad Lerma. Av. de las Garzas
No. 10, Col. el Panteón, Lerma de Villada, Estado de México, C.P. 52005, Mexico.
(3)División de Neurociencias. Instituto de Fisiología Celular. Universidad
Nacional Autónoma de México (UNAM). Circuito Exterior, Ciudad Universitaria,
04510 Mexico City.
(4)Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro Laboratory, 146 rue
Léo Saignat, 33076 Bordeaux, France.
(5)Université de Bordeaux, Nutrition and Integrative Neurobiology, UMR 1286,
Bordeaux, France.
(6)Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la
Salud. Universidad Autónoma Metropolitana (UAM), Unidad Lerma. Av. de las Garzas
No. 10, Col. el Panteón, Lerma de Villada, Estado de México, C.P. 52005, Mexico.
Electronic address: .
Childhood and adolescent exposure to obesogenic environments has contributed to
the development of several health disorders, including neurocognitive impairment.
Adolescence is a critical neurodevelopmental window highly influenced by
environmental factors that affect brain function until adulthood. Post-weaning
chronic exposure to a high-fat diet (HFD) adversely affects memory performance;
physical activity is one approach to coping with these dysfunctions. Previous
studies indicate that voluntary exercise prevents HFD’s detrimental effects on
memory; however, it remains to evaluate whether it has a remedial/therapeutical
effect when introduced after a long-term HFD exposure. This study was conducted
on a diet-induced obesity mice model over six months. After three months of HFD
exposure (without interrupting the diet) access to voluntary physical activity
was provided. HFD produced weight gain, increased adiposity, and impaired glucose
tolerance. Voluntary physical exercise ameliorated glucose tolerance and halted
weight gain and fat accumulation. Additionally, physical activity mitigated
HFD-induced spatial and recognition memory impairments. Our data indicate that
voluntary physical exercise starting after several months of periadolescent HFD
exposure reverses metabolic and cognitive alterations demonstrating that
voluntary exercise, in addition to its known preventive effect, also has a
restorative impact on metabolism and cognition dysfunctions associated with
obesity.
Copyright © 2022. Published by Elsevier Inc.