Visualization of disconnection syndromes in humans
Cortex. 2008-09-01; 44(8): 1097-1103
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1. Cortex. 2008 Sep;44(8):1097-103. doi: 10.1016/j.cortex.2008.02.003. Epub 2008 May
Visualization of disconnection syndromes in humans.
Thiebaut de Schotten M(1), Kinkingnéhun S, Delmaire C, Lehéricy S, Duffau H,
Thivard L, Volle E, Levy R, Dubois B, Bartolomeo P.
(1)Hôpital de la Salpêtrière, Paris, France.
Knowledge of the relationship between structure and function is essential to the
exploration of the architecture of cognition. Cognitive processes require the
coordinated activity of large-scale brain networks consisting of distant cortical
regions, connected by long-range white matter tracts. Despite decades of
connectional tracing studies in monkeys, the backwardness of human anatomy makes
it difficult to draw conclusions from lesion studies and functional neuroimaging
when brain connectivity is at issue. We propose an approach to clinico-anatomical
correlation, based on a standardized atlas of white matter tracts derived from
diffusion tensor imaging tractography. Using OVER-TRACK, a method based on
tracking and overlapping white matter tracts, we mapped the course of three
rostro-caudal association pathways in the Montreal Neurological Institute space.
For each voxel we defined the probability of finding fibers belonging to
individual tracts. This method is defined to localize in the white matter the
overlapping lesion derived from a group of patients with brain damage. Our study
provides a general approach for establishing anatomo-functional correlations by
estimating the cortical areas connected in normal subjects, or disconnected by
white matter lesions. This method will help researchers and clinicians to
identify the neural bases of cognitive abilities and the behavioral consequences
of brain lesions.
PMID: 18602092 [Indexed for MEDLINE]