Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine.

Christelle Glangetas, Giulia R. Fois, Marion Jalabert, Salvatore Lecca, Kristina Valentinova, Frank J. Meye, Marco Diana, Philippe Faure, Manuel Mameli, Stéphanie Caille, François Georges
Cell Reports. 2015-12-01; 13(10): 2287-2296
DOI: 10.1016/j.celrep.2015.10.076

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1. Cell Rep. 2015 Dec 15;13(10):2287-96. doi: 10.1016/j.celrep.2015.10.076. Epub
2015 Nov 25.

Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine
Neurons and Facilitates Behavioral Effects of Cocaine.

Glangetas C(1), Fois GR(1), Jalabert M(2), Lecca S(3), Valentinova K(3), Meye
FJ(3), Diana M(4), Faure P(5), Mameli M(3), Caille S(6), Georges F(7).

Author information:
(1)Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297,
33076 Bordeaux, France; Centre National de la Recherche Scientifique,
Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
(2)Université de la Méditerranée, UMR S901, Aix-Marseille 2, 13009 Marseille,
France; INSERM-INMED, UMR 901, 13009 Marseille, France.
(3)Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005
Paris, France.
(4)”G. Minardi” Cognitive Neuroscience Laboratory, Department of Chemistry and
Pharmacy, University of Sassari, 07100 Sassari, Italy.
(5)CNRS, UMR8246 NPS, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris
06, UM119, NPS, 75005 Paris, France; INSERM, U1130 NPS, 75005 Paris, France.
(6)Université de Bordeaux, INCIA, BP31, 33076 Bordeaux, France; CNRS, UMR5287
INCIA, 33076 Bordeaux, France.
(7)Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297,
33076 Bordeaux, France; Centre National de la Recherche Scientifique,
Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
Electronic address: .

The ventral subiculum (vSUB) plays a key role in addiction, and identifying the
neuronal circuits and synaptic mechanisms by which vSUB alters the excitability
of dopamine neurons is a necessary step to understand the motor changes induced
by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB)
over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers
long-lasting modifications of synaptic transmission measured ex vivo. This
potentiation is caused by NMDA-dependent plastic changes occurring in the bed
nucleus of the stria terminalis (BNST). Finally, we report that the modification
of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity
induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal
circuit encoding behavioral effects of cocaine in rats and highlight the
importance of adaptive modifications in the BNST, a structure that influences
motivated behavior as well as maladaptive behaviors associated with addiction.

Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

DOI: 10.1016/j.celrep.2015.10.076
PMID: 26628379 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus