Vascular Cerebral Damage in Frail Older Adults: The AMImage Study.
The Journals of Gerontology: Series A. 2017-01-21; 72(7): 971-977
DOI: 10.1093/gerona/glw347
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1. J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):971-977. doi:
10.1093/gerona/glw347.
Vascular Cerebral Damage in Frail Older Adults: The AMImage Study.
Avila-Funes JA(1)(2)(3), Pelletier A(2)(3), Meillon C(2)(3), Catheline
G(4)(5)(6), Periot O(7), Trevin O-Frenk I(8)(9), Gonzalez-Colaço M(2)(3),
Dartigues JF(2)(3), Pérès K(2)(3), Allard M(4)(5)(6)(7), Dilharreguy B(4)(5)(6),
Amieva H(2)(3).
Author information:
(1)Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición
Salvador Zubirán, Mexico City, Mexico.
(2)Université de Bordeaux, France.
(3)Centre de recherche INSERM U1219, Bordeaux, France.
(4)Univ. Bordeaux, INCIA, UMR 5287, Bordeaux, France.
(5)CNRS, INCIA, UMR 5287, Bordeaux, France.
(6)EPHE, Bordeaux, France.
(7)CHU de Bordeaux, France.
(8)Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas
y Nutrición Salvador Zubirán, Mexico City, Mexico.
(9)Neurologic Center, Centro Médico ABC, Mexico City, Mexico.
Background: Frailty has been associated with increased risk of adverse-health
related outcomes including cognitive impairment. However, little is know about
the pathogenesis relating frailty to cognitive decline. Therefore, the main
objective of this study was to investigate the association between vascular
cerebral damage and frailty.
Methods: Cross-sectional study involving 176 community-dwelling participants aged
67-86 years, participating in the AMImage Study, an ancillary neuro-imaging
project of the AMI cohort, a French prospective cohort including older farmers
living in rural areas. Frailty was defined as proposed by Fried. 3T magnetic
resonance imaging (MRI) examination was performed with anatomical, diffusion, and
fluid-attenuated inversion recovery sequences. The evaluation included the
assessment of white matter hyperintensities (WMH) volumes and of microstructural
white matter integrity through exploration of diffusion tensor imaging (DTI)
parameters.
Results: The analyses showed that WMH volumes were higher in frail persons
compared with nonfrail subgroup. Frail participants presented DTI modifications
in extensive areas of white matter. In comparison with nonfrail subgroup, frail
participants showed a strong association between WMH volumes and DTI changes.
Conclusion: These results show that subclinical cerebrovascular damage is present
in the frail older person, which could support the hypothesis that frailty is a
prodromal state of central nervous system vascular injury.
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DOI: 10.1093/gerona/glw347
PMID: 28329104 [Indexed for MEDLINE]