Variations of planum temporale asymmetries with Heschl’s Gyri duplications and association with cognitive abilities: MRI investigation of 428 healthy volunteers

Nathalie Tzourio-Mazoyer, B. Mazoyer
Brain Struct Funct. 2017-02-06; 222(6): 2711-2726
DOI: 10.1007/s00429-017-1367-5

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1. Brain Struct Funct. 2017 Aug;222(6):2711-2726. doi: 10.1007/s00429-017-1367-5.
Epub 2017 Feb 6.

Variations of planum temporale asymmetries with Heschl’s Gyri duplications and
association with cognitive abilities: MRI investigation of 428 healthy
volunteers.

Tzourio-Mazoyer N(1)(2)(3)(4), Mazoyer B(5)(6)(7)(8).

Author information:
(1)Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
.
(2)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
.
(3)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
.
(4)IMN Institut des Maladies Neurodégénératives UMR 5293, Team 5: GIN Groupe
d’Imagerie Neurofonctionnelle, CEA-CNRS-Université de Bordeaux, 146 rue Léo
Saignat-CS 61292-Case 28, 33076, Bordeaux cedex, France.
.
(5)Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
(6)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(7)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
(8)IMN Institut des Maladies Neurodégénératives UMR 5293, Team 5: GIN Groupe
d’Imagerie Neurofonctionnelle, CEA-CNRS-Université de Bordeaux, 146 rue Léo
Saignat-CS 61292-Case 28, 33076, Bordeaux cedex, France.

In a large sample of 428 healthy adults balanced for gender and manual preference
(MP), we investigated planum temporale (PT) surface area variability in relation
with Heschl’s gyrus (HG) duplication pattern, MP, and familial sinistrality (FS),
considering different PT definitions. In a sub-sample of 362 participants, we
also investigated whether variability of PT asymmetry was associated with
differences in verbal abilities. On each participant brain hemisphere MRI, we
delineated a posterior PT area (PTpost), excluding the second Heschl gyrus in
case of either complete posterior duplication (CPD) or common stem partial
duplication (CSD). We then defined a total PT area (PTtot) as the union of PTpost
and of the second HG when present, and a HGPT area as the union of PTtot and of
the first HG. The HG duplication pattern of one hemisphere was found to
significantly affect the PTpost surface area of the same hemisphere, a larger
reduction being present in case of CPD than in case of CSD, leading to a strong
impact of both left and right HG duplication patterns on PTpost asymmetry. The HG
duplication pattern had no effect on PTtot surface areas, while a significant
effect of the left HG duplication was present on PTtot asymmetry that was larger
in case of a CSD as compared to a single HG. By contrast, the type of HG
duplication did not affect HGPT and neither left nor right HG duplication pattern
had an effect on HGPT asymmetry. Meanwhile, MP had no effect on PTpost, PTtot,
HGPT, or their asymmetries. The absence of a left PTpost was associated with
existence of FS (FS+) (7FS+ among nine without PTpost). Removing the nine
individuals lacking PTpost, a lower left PTpost surface area was observed in FS+
participants with left CPD. In the sub-sample of 362 participants, we observed a
significant interaction between PTpost asymmetry and cognitive abilities due to
poorer lexical performances in individuals having a symmetric PTpost as compared
to individuals having either a leftward or a rightward asymmetric PTpost. By
contrast, there was no significant effect of PTtot or HGPT asymmetry on cognitive
abilities. This study shows that HG duplication pattern mainly affects the
surface area of the most posterior part of PT and its asymmetry, this PTpost area
being specifically associated with variability in verbal performances. This study
also shows, for the first time, an association between decreased performances and
lack of PTpost anatomical asymmetry, being rightward asymmetrical having no
deleterious effect on verbal abilities, thereby supporting the idea that
anatomical lateralization is necessary for optimal verbal performances.

DOI: 10.1007/s00429-017-1367-5
PMID: 28164245 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus