Variability of average SUV from several hottest voxels is lower than that of SUVmax and SUVpeak
Eur Radiol. 2014-06-04; 24(8): 1964-1970
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1. Eur Radiol. 2014 Aug;24(8):1964-70. doi: 10.1007/s00330-014-3222-x. Epub 2014 Jun
Variability of average SUV from several hottest voxels is lower than that of
SUVmax and SUVpeak.
Laffon E(1), Lamare F, de Clermont H, Burger IA, Marthan R.
(1)Service de Médecine Nucléaire, Hôpital du Haut-Lévèque, CHU de Bordeaux,
Avenue de Magellan, 33604, Pessac, France, .
OBJECTIVES: To assess variability of the average standard uptake value (SUV)
computed by varying the number of hottest voxels within an
(18)F-fluorodeoxyglucose ((18)F-FDG)-positive lesion. This SUV metric was
compared with the maximal SUV (SUV(max): the hottest voxel) and peak SUV
(SUV(peak): SUV(max) and its 26 neighbouring voxels).
METHODS: Twelve lung cancer patients (20 lesions) were analysed using PET dynamic
acquisition involving ten successive 2.5-min frames. In each frame and lesion,
average SUV obtained from the N = 5, 10, 15, 20, 25 or 30 hottest voxels
(SUV(max-N)), SUV(max) and SUV(peak) were assessed. The relative standard
deviations (SDrs) from ten frames were calculated for each SUV metric and lesion,
yielding the mean relative SD from 20 lesions for each SUV metric (SDr(N),
SDr(max) and SDr(peak)), and hence relative measurement error and repeatability
RESULTS: For each N, SDr(N) was significantly lower than SDr(max) and SDr(peak).
SDr(N) correlated strongly with N: 6.471 × N(-0.103) (r = 0.994; P