Use of anatomical parcellation to catalog and study structure-function relationships in the human brain

Natalie Tzourio, Laurent Petit, Emmanuel Mellet, Christophe Orssaud, Fabrice Crivello, Karim Benali, Georges Salamon, Bernard Mazoyer
Hum. Brain Mapp.. 1997-01-01; 5(4): 228-232

We describe a functional neuroanatomy approach that combines structural (MRI) and functional(PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemispheresurface rendering and sections and stored. Using these landmarks, the subject brain volume is then dividedin 100 anatomical volumes of interest (AVOI). AVOI morphometric measurements are readily obtained aswell as functional parameters (CBF) after MRI-PET alignment. This approach allows structure-functionrelationship investigations both at the single case and at the intersubject average level; in addition,individual morphometric and functional parameters can be easily archieved in a database for furthermeta-analysis. This approach is applicable to all imaging modalities and is especially suited for a priorihypothesis testing and for the investigation of interindividual functional neuroanatomy variability.

Hum.Brain Mapping 5:228–232, 1997.r1997Wiley-Liss,Inc.

Key words: MRI; PET; anatomical volumes of interest; structure-function relationships; database; neuro-anatomy; brain activation

Auteurs Bordeaux Neurocampus