Transient neonatal thyrotoxicosis: clinical presentation and treatment in 7 cases,Complications cliniques et difficultés de prise en charge de l’hyperthyroïdie néonatale transmise
Archives de Pédiatrie. 2007-11-01; 14(11): 1310-1314
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1. Arch Pediatr. 2007 Nov;14(11):1310-4. Epub 2007 Jul 24.
[Transient neonatal thyrotoxicosis: clinical presentation and treatment in 7
[Article in French]
Vautier V(1), Moulin P, Guérin B, Barat P.
(1)Service d’endocrinologie et de diabétologie pédiatrique, hôpital des enfants,
place Raba-Léon, 33000 Bordeaux, France.
Neonatal thyrotoxicosis is a rare disease. The goal of this study was to analyse
main neonatal symptoms, clinical complications and patient’s care.MATERIAL AND
METHODS: This retrospective study concerned the newborns admitted with neonatal
thyrotoxicosis between 1992 and 2004 in the neonatal department of Bordeaux,
Toulouse and Pau hospital.
RESULTS: Seven of these patients were included in the study. All of the newborns
had permanent tachycardia and 3 of them had respiratory failure. Two patients had
potentially lethal clinical complications. The first had goitre with tracheal
compression. The second developed global heart failure on his 13th day of life.
The onset of antithyroid drug treatment was between the 3rd and the 18th day of
life. Mean duration of treatment was 50 days. Occurring complications were
neutropenia in 3 patients and hypothyroidism in 1 patient. The children were
tracked during their first year, and all had normal growth and normal
CONCLUSION: The main prognostic factor is the early onset of antithyroid
treatment. In our study, 2 patients had potentially lethal clinical
complications. Adequate care depends on early spotting of high-risk newborn.
PMID: 17651947 [Indexed for MEDLINE]