Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption, via hippocampal thyroid hormone signaling
Molecular Metabolism. 2024-12-01; 90: 102061
DOI: 10.1016/j.molmet.2024.102061
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1. Mol Metab. 2024 Dec;90:102061. doi: 10.1016/j.molmet.2024.102061. Epub 2024
Nov 6.
Time-restricted feeding prevents memory impairments induced by obesogenic diet
consumption, via hippocampal thyroid hormone signaling.
Helbling JC(1), Ginieis R(1), Mortessagne P(1), Ruiz-Gayo M(2), Bakoyiannis
I(1), Ducourneau EG(1), Ciocca D(3), Bouleté IM(3), Favereaux A(4), Ces A(5),
Montalban E(1), Capuron L(1), Jeanneteau F(6), Ferreira G(1), Challet E(5),
Moisan MP(7).
Author information:
(1)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Teams NutriPsy &
FoodCircus, Bordeaux, France.
(2)Department of Health and Pharmaceutical Sciences, Facultad de Farmacia,
Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
(3)Chronobiotron, Centre National de la Recherche Scientifique (CNRS),
University of Strasbourg, France.
(4)Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR
5297, Bordeaux, France.
(5)Institute of Cellular and Integrative Neurosciences, CNRS, University of
Strasbourg, France.
(6)Institut de Génomique Fonctionnelle, Université de Montpellier, INSERM, CNRS,
Montpellier, France.
(7)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Teams NutriPsy &
FoodCircus, Bordeaux, France. Electronic address: .
OBJECTIVE: The early consumption of calorie-rich diet disrupts circadian rhythms
and has adverse effects on memory, yet the effects of time-restricted feeding
(TRF) and the underlying molecular mechanisms are unknown. Here, we set out to
identify the behavioral and molecular circadian rhythms disruptions generated by
juvenile obesogenic diet consumption and their restoration by TRF in male mice.
METHODS: Metabolic rhythms were measured by indirect calorimetry and memory
performances by behavioral tasks. Hippocampal translatome (pS6_TRAP), enrichment
and co-regulated gene network analyses were conducted to identify the molecular
pathways involved in memory impairments and their restoration by TRF.
Differential exon usage analyses, mass spectrometry and pharmacological
intervention were used to confirm thyroid hormone signaling involvement.
RESULTS: We show that four weeks of TRF restore the rhythmicity of metabolic
parameters and prevents memory impairments in mice fed a high fat-high sucrose
(HFS) diet since weaning, independently of body fat levels. Hippocampal
translatome and differential exon usage analyses indicate that impaired memory
of mice under ad libitum HFS diet is accompanied by reduced thyroid hormone
signaling and altered expression of astrocytic genes regulating glutamate
neurotransmission. TRF restored the diurnal expression variation of part of
these genes and intra-hippocampal infusion of T3, the active form of thyroid
hormone, rescues memory performances and astrocytic gene expression of ad
libitum HFS diet-fed mice.
CONCLUSIONS: Thus, thyroid hormones contribute to the TRF positive effects on
both metabolism and memory in mice fed an obesogenic diet, highlighting this
nutritional approach as a powerful tool in addressing obesity brain
comorbidities and paving the way for further mechanistic studies on hippocampal
thyroid signaling.
Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights
reserved.
DOI: 10.1016/j.molmet.2024.102061
PMID: 39515608 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest The authors
declare that they have no known competing financial interests or personal
relationships that could have appeared to influence the work reported in this
paper.