The role of diffusion MRI in neuroscience
NMR in Biomedicine. 2017-07-11; 32(4): e3762
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1. NMR Biomed. 2019 Apr;32(4):e3762. doi: 10.1002/nbm.3762. Epub 2017 Jul 11.
The role of diffusion MRI in neuroscience.
Assaf Y(1)(2), Johansen-Berg H(3), Thiebaut de Schotten M(4)(5)(6).
(1)Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
(2)Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv
University, Tel Aviv, Israel.
(3)FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of
Oxford, John Radcliffe Hospital, Oxford, UK.
(4)Brain Connectivity and Behaviour Group, Frontlab, Brain and Spine Institute,
(5)Sorbonne Universités, UPMC Université Paris 06, Inserm, CNRS, Institut du
cerveau et la moelle (ICM) – Hôpital Pitié-Salpêtrière, Boulevard de l’hôpital,
(6)Centre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier
Pitié-Salpêtrière, Paris, France.
Diffusion-weighted imaging has pushed the boundaries of neuroscience by allowing
us to examine the white matter microstructure of the living human brain. By doing
so, it has provided answers to fundamental neuroscientific questions, launching a
new field of research that had been largely inaccessible. We briefly summarize
key questions that have historically been raised in neuroscience concerning the
brain’s white matter. We then expand on the benefits of diffusion-weighted
imaging and its contribution to the fields of brain anatomy, functional models
and plasticity. In doing so, this review highlights the invaluable contribution
of diffusion-weighted imaging in neuroscience, presents its limitations and
proposes new challenges for future generations who may wish to exploit this
powerful technology to gain novel insights.
Copyright © 2017 John Wiley & Sons, Ltd.