The pathologic features of neurocutaneous melanosis in a cynomolgus macaque.

Y. Chen, W. Deng, H. Zhu, J. Li, Y. Xu, X. Dai, C. Jia, Q. Kong, L. Huang, Y. Liu, C. Ma, C. Xiao, Q. Li, E. Bezard, C. Qin
Vet Pathol. 2009-03-09; 46(4): 773-775
DOI: 10.1354/vp.08-vp-0243-q-bc

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1. Vet Pathol. 2009 Jul;46(4):773-5. doi: 10.1354/vp.08-VP-0243-Q-BC. Epub 2009 Mar

The pathologic features of neurocutaneous melanosis in a cynomolgus macaque.

Chen Y(1), Deng W, Zhu H, Li J, Xu Y, Dai X, Jia C, Kong Q, Huang L, Liu Y, Ma C,
Xiao C, Liu Y, Li Q, Bezard E, Qin C.

Author information:
(1)Department of Pathology, Institute of Laboratory Animal Science, Chinese
Academy of Medical Sciences and Peking Union Medical College, No. 5, Panjiayuan,
Nanli, Chaoyang District, Beijing, 100021, People’s Republic of China.

Neurocutaneous melanosis (NCM) is a rare phakomatosis characterized by
proliferation of melanin-producing cells in both the skin and the brain. In this
study, we describe the clinical and pathologic features of NCM in a 4.5-year-old
female cynomolgus macaque. Histopathologically, skin lesions showed foci of nests
and cords of pigmented cells in the dermis similar to blue nevi in humans. In the
brain, focal pigmented cell infiltration was observed in the connective tissue
under the leptomeninges and in the brain parenchyma. The pigmented cell was
moderately reactive with a pan-melanoma antibody (melanoma(pan)) in the skin. In
the brain, the pigmented cell was moderately to strongly positive for
melanoma(pan) in subleptomeningeal areas and in the cerebral cortex. Melanosomes
were observed in pigmented cells in the brain by electron microscopic
examination. Based on the histologic, immunohistochemical, and electron
microscopic results, the diagnosis of NCM was made. This case is possibly the
first report of the condition in animals.

DOI: 10.1354/vp.08-VP-0243-Q-BC
PMID: 19276048 [Indexed for MEDLINE]

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