The neuropeptide SMYamide, a SIFamide paralog, is expressed by salivary gland innervating neurons in the American cockroach and likely functions as a hormone.
Peptides. 2021-02-01; 136: 170466
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(1)INCIA, UMR 5287, CNRS, Université de Bordeaux, Allée Geoffroy St Hillaire, CS
50023, 33 615, Pessac Cedex, France. Electronic address:
The SMYamide genes are paralogs of the SIFamide genes and code for neuropeptides
that are structurally similar to SIFamide. In the American cockroach, Periplanea
americana, the SMYamide gene is specifically expressed in the SN2 neurons that
innervate the salivary glands and are known to produce action potentials during
feeding. The SN2 axon terminals surround rather than directly innervate the
salivary gland acini. Therefore one may expect that on activation of these
neurons significant amounts of SMYamide will be released into the hemolymph, thus
suggesting that SMYamide may also have a hormonal function. In the Periplaneta
genome there are two putative SIFamide receptors and these are both expressed not
only in the central nervous system and the salivary gland, but also in the gonads
and other peripheral tissues. This reinforces the hypothesis that SMYamide also
has an endocrine function in this species.
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