The neuropeptide SIFamide modulates sexual behavior in Drosophila

Selim Terhzaz, Philippe Rosay, Stephen F. Goodwin, Jan A. Veenstra
Biochemical and Biophysical Research Communications. 2007-01-01; 352(2): 305-310
DOI: 10.1016/j.bbrc.2006.11.030

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1. Biochem Biophys Res Commun. 2007 Jan 12;352(2):305-10. Epub 2006 Nov 15.

The neuropeptide SIFamide modulates sexual behavior in Drosophila.

Terhzaz S(1), Rosay P, Goodwin SF, Veenstra JA.

Author information:
(1)Laboratoire de Neurosciences Cognitives, Unité Mixte de Recherche 5106
CNRS/Université Bordeaux I Avenue des Facultés, F-33405 Talence Cedex, France.

The expression of Drosophila neuropeptide AYRKPPFNGSIFamide (SIFamide) was shown
by both immunohistology and in situ hybridization to be restricted to only four
neurons of the pars intercerebralis. The role of SIFamide in adult courtship
behavior in both sexes was studied using two different approaches to perturb the
function of SIFamide; targeted cell ablation and RNA interference (RNAi).
Elimination of SIFamide by either of these methods results in promiscuous flies;
males perform vigorous and indiscriminant courtship directed at either sex, while
females appear sexually hyper-receptive. These results demonstrate that SIFamide
is responsible for these behavioral effects and that the four SIFamidergic
neurons and arborizations play an important function in the neuronal circuitry
controlling Drosophila sexual behavior.

DOI: 10.1016/j.bbrc.2006.11.030
PMID: 17126293 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus