The menace of obesity to depression and anxiety prevalence
Trends in Endocrinology & Metabolism. 2022-01-01; 33(1): 18-35
DOI: 10.1016/j.tem.2021.10.005
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1. Trends Endocrinol Metab. 2022 Jan;33(1):18-35. doi: 10.1016/j.tem.2021.10.005.
Epub 2021 Nov 5.
The menace of obesity to depression and anxiety prevalence.
Fulton S(1), Décarie-Spain L(2), Fioramonti X(3), Guiard B(4), Nakajima S(5).
Author information:
(1)Centre de Recherche du Centre Hospitalier de l’Université de Montréal
(CRCHUM), Department of Nutrition, Université de Montréal, Montréal, QC H3T1J4,
Canada. Electronic address: .
(2)Centre de Recherche du Centre Hospitalier de l’Université de Montréal
(CRCHUM), Department of Neuroscience, Université de Montréal, Montréal, QC
H3T1J4, Canada.
(3)NutriNeuro, UMR 1286 INRAE, Bordeaux INP, Bordeaux University, Bordeaux,
France.
(4)Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie
Intégrative (CBI), CNRS UMR5169, UPS, Université de Toulouse, Toulouse, France.
(5)Centre de Recherche du Centre Hospitalier de l’Université de Montréal
(CRCHUM), Department of Nutrition, Université de Montréal, Montréal, QC H3T1J4,
Canada.
The incidence of depression and anxiety is amplified by obesity. Mounting
evidence reveals that the psychiatric consequences of obesity stem from poor
diet, inactivity, and visceral adipose accumulation. Resulting metabolic and
vascular dysfunction, including inflammation, insulin and leptin resistance, and
hypertension, have emerged as key risks to depression and anxiety development.
Recent research advancements are exposing the important contribution of these
different corollaries of obesity and their impact on neuroimmune status and the
neural circuits controlling mood and emotional states. Along these lines, this
review connects the clinical manifestations of depression and anxiety in obesity
to our current understanding of the origins and biology of immunometabolic
threats to central nervous system function and behavior.
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.tem.2021.10.005
PMID: 34750064 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests No interests are
declared.