The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study.
Journal of Stroke and Cerebrovascular Diseases. 2019-05-01; 28(5): 1236-1242
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Sagnier S(1), Munsch F(2), Bigourdan A(2), Debruxelles S(3), Poli M(3), Renou P(3), Olindo S(3), Rouanet F(3), Dousset V(2), Tourdias T(2), Sibon I(4).
(1)UMR-5287 CNRS, Université de Bordeaux, EPHE PSL Research University, Bordeaux, France; CHU de Bordeaux, Unité Neuro-vasculaire, Bordeaux, France.
(2)CHU de Bordeaux, Neuroradiologie, Bordeaux, France; Neurocentre Magendie INSERM-U1215, Université de Bordeaux, Bordeaux, France.
(3)CHU de Bordeaux, Unité Neuro-vasculaire, Bordeaux, France.
(4)UMR-5287 CNRS, Université de Bordeaux, EPHE PSL Research University, Bordeaux, France; CHU de Bordeaux, Unité Neuro-vasculaire, Bordeaux, France.
BACKGROUND AND PURPOSE: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome.
MATERIALS AND METHODS: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. A 3 Tesla brain MRI was performed at baseline. Mood and cognition were assessed using Hospital Anxiety and Depression scale (HAD), apathy inventory (AI), and Montreal Cognitive Assessment scale subscores, performed at 3 months poststroke. Statistical maps of ischemic stroke location associated with 3 months mood and cognitive scores were obtained using a voxel-based lesion-symptom mapping approach (Brunner and Munzel test). Significant voxels (false discovery rate [FDR] corrected-P < .01) were identified using the standard Montreal Neurological Institute-152 space template.
RESULTS: Two hundred and sixty-five nonsevere stroke patients were included (64% men, mean age 66 ± 14, median National Institute of Health Stroke Score 3, interquartile range 2-6). Ischemic stroke location was not associated with HAD or AI scores. Language, abstraction, and delayed recall performances were mainly associated with left-side hemispheric lesions. Lesions in both hemispheres were associated with lower performances in visuospatial and executive functions, naming, attention, and orientation.
CONCLUSION: Ischemic stroke location does not predict mood outcome at 3 months but is a determinant of cognitive outcome in specific domains.