The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology.
Mol Psychiatry. 2010-11-19; 15(12): 1128-1139
DOI: 10.1038/mp.2010.4
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Schumann G(1), Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ,
Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik
C, Mann K, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Reed L,
Smolka M, Spanagel R, Speiser C, Stephens DN, Ströhle A, Struve M; IMAGEN
consortium.
Collaborators: Schumann G, Conrod P, Reed L, Barker G, Williams S, Loth E, Struve
M, Lourdusamy A, Costafreda S, Cattrell A, Nymberg C, Topper L, Smith L,
Havatzias S, Stueber K, Mallik C, Clarke TK, Stacey D, Peng Wong C, Werts H,
Williams S, Andrew C, Desrivieres S, Zewdie S, Heinz A, Gallinat J, Häke I,
Ivanov N, Klär A, Reuter J, Palafox C, Hohmann C, Schilling C, Lüdemann K,
Romanowski A, Ströhle A, Wolff E, Rapp M, Ittermann B, Brühl R, Ihlenfeld A,
Walaszek B, Schubert F, Garavan H, Connolly C, Jones J, Lalor E, McCabe E, Ní
Shiothcháin A, Whelan R, Spanagel R, Leonardi-Essmann F, Sommer W, Flor H,
Vollstaedt-Klein S, Nees F, Banaschewski T, Poustka L, Steiner S, Mann K, Buehler
M, Rietschel M, Stolzenburg E, Schmal C, Schirmbeck F, Paus T, Gowland P, Heym N,
Lawrence C, Newman C, Pausova Z, Smolka M, Huebner T, Ripke S, Mennigen E, Muller
K, Ziesch V, Büchel C, Bromberg U, Fadai T, Lueken L, Yacubian J, Finsterbusch J,
Martinot JL, Artiges E, Bordas N, de Bournonville S, Bricaud Z, Gollier Briand F,
Lemaitre H, Massicotte J, Miranda R, Paillère Martinot ML, Penttilä J, Poline JB,
Barbot A, Schwartz Y, Lalanne C, Frouin V, Thyreau B, Dalley J, Mar A, Robbins T,
Subramaniam N, Theobald D, Richmond N, de Rover M, Molander A, Jordan E, Robinson
E, Hipolata L, Moreno M, Arroyo M, Stephens D, Ripley T, Crombag H, Pena Y,
Lathrop M, Zelenika D, Heath S, Lanzerath D, Heinrichs B, Spranger T, Fuchs B,
Speiser C, Resch F, Haffner J, Parzer P, Brunner R, Klaassen A, Klaassen I,
Constant P, Mignon X, Thomsen T, Zysset S, Vestboe A, Ireland J, Rogers J.
Author information:
(1)King’s College London, MRC Social, Genetic, and Developmental Psychiatry
Centre, Institute of Psychiatry, London, UK.
A fundamental function of the brain is to evaluate the emotional and motivational
significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is
the first multicentre genetic-neuroimaging study aimed at identifying the genetic
and neurobiological basis of individual variability in impulsivity, reinforcer
sensitivity and emotional reactivity, and determining their predictive value for
the development of frequent psychiatric disorders. Comprehensive behavioural and
neuropsychological characterization, functional and structural neuroimaging and
genome-wide association analyses of 2000 14-year-old adolescents are combined
with functional genetics in animal and human models. Results will be validated in
1000 adolescents from the Canadian Saguenay Youth Study. The sample will be
followed up longitudinally at the age of 16 years to investigate the predictive
value of genetics and intermediate phenotypes for the development of frequent
psychiatric disorders. This review describes the strategies the IMAGEN consortium
used to meet the challenges posed by large-scale multicentre imaging-genomics
investigations. We provide detailed methods and Standard Operating Procedures
that we hope will be helpful for the design of future studies. These include
standardization of the clinical, psychometric and neuroimaging-acquisition
protocols, development of a central database for efficient analyses of large
multimodal data sets and new analytic approaches to large-scale genetic
neuroimaging analyses.