The growing incidence of type 1 diabetes in children: The 17-year French experience in Aquitaine
Diabetes & Metabolism. 2008-12-01; 34(6): 601-605
DOI: 10.1016/j.diabet.2008.06.002
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1. Diabetes Metab. 2008 Dec;34(6 Pt 1):601-5. doi: 10.1016/j.diabet.2008.06.002.
Epub 2008 Oct 25.
The growing incidence of type 1 diabetes in children: the 17-year French
experience in Aquitaine.
Barat P(1), Valade A, Brosselin P, Alberti C, Maurice-Tison S, Lévy-Marchal C.
Author information:
(1)Unité de pédiatrie endocrinologique et diabétologique, hôpital
Pellegrin-Enfants, centre hospitalier universitaire de Bordeaux, 33076 Bordeaux,
France.
BACKGROUND: While the incidence of type 1 diabetes in children has increased in
various parts of the world, in France, no actual figures have been available
since 1997.
OBJECTIVE: The aim of this study was to determine whether or not the pattern of
increase in the incidence of type 1 diabetes in children aged less than 15 years
varies with age at onset in Aquitaine (France) over a 17-year period.
PATIENTS AND METHODS: From 1988 to 1997, all newly diagnosed cases of type 1
diabetes were confirmed by registration into the French Registry of Incidence of
Diabetes. Subsequently, all cases registered from 1998 to 2004 were collected
within paediatric centres in Aquitaine as part of their hospital-based
prospective records.
RESULTS: In the overall population, the age- and gender-adjusted incidence rate
increased from 8.86 per 100,000 per year (95% CI: 6.27-11.45) in 1988 to 13.47
per 100,000 per year (95% CI: 10.29-16.65) in 2004, indicating an annual increase
in incidence of 3.34% (95% CI: 3.33-3.34). Median age at diabetes onset for cases
in the first registration period (1988-1996) was significantly higher than that
in the second registration period (1997-2004): 10.04 years (range: 6.64-12.53)
versus 8.83 years (range: 5.48-11.73), respectively (P=0.01). The annual increase
in incidence rate was highest in the youngest children and varied significantly
with age (0-4 years: 7.59%; 5-9 years: 4.06%; 10-14 years: 1.28%).
CONCLUSION: These results indicate a doubling of the incidence of type 1 diabetes
in children every 30 years in Aquitaine, with an even steeper increase among
younger children, thus underscoring the need for appropriate adaptation of the
system of healthcare provision.
DOI: 10.1016/j.diabet.2008.06.002
PMID: 18952477 [Indexed for MEDLINE]