The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats
Journal of Neuroscience Methods. 2004-09-01; 138(1-2): 207-216
DOI: 10.1016/j.jneumeth.2004.04.019
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1. J Neurosci Methods. 2004 Sep 30;138(1-2):207-16.
The effects of electrode material, charge density and stimulation duration on the
safety of high-frequency stimulation of the subthalamic nucleus in rats.
Harnack D(1), Winter C, Meissner W, Reum T, Kupsch A, Morgenstern R.
Author information:
(1)Department of Neurology, Charité Campus Virchow, Berlin, Germany.
High-frequency stimulation (HFS) of deep brain structures is a powerful
therapeutic tool for the treatment of various movement disorders in patients.
However, the pathophysiological mechanisms of this therapeutic approach on basal
ganglia network function are still largely unknown. Hitherto, experimental
studies have focused on short-term stimulation. Since patients receive HFS for
many years, animal studies which reproduce the conditions of long-term
stimulation will be necessary to accurately investigate the effects of HFS.
However, stimulation parameters of acute HFS cannot be easily transferred to
long-term conditions. Accordingly, for this purpose we studied the influence of
different charge densities (0, 3, 6.5, 13 and 26 microC/cm2/phase) and duration
(4 h or 3 days) of subthalamic nucleus (STN)-HFS using stainless-steel and
platinum-iridium (Pt/Ir) electrodes on neuronal tissue damage in rats. Our data
demonstrate the advantage of Pt/Ir over stainless-steel electrodes when used in
short-term HFS (frequency 130 Hz, pulse width 60 micros) and indicate that HFS
using Pt/Ir-electrodes pulsed with 3 microC/cm2/phase over 3 days did not produce
any relevant tissue damage in the STN.
DOI: 10.1016/j.jneumeth.2004.04.019
PMID: 15325129 [Indexed for MEDLINE]