The deafferented nonhuman primate is not a reliable model of intractable pain.
Neurological Research. 2003-03-01; 25(2): 127-129
DOI: 10.1179/016164103101201274
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1. Neurol Res. 2003 Mar;25(2):127-9.
The deafferented nonhuman primate is not a reliable model of intractable pain.
Pioli EY(1), Gross CE, Meissner W, Bioulac BH, Bezard E.
Author information:
(1)Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR, 5543, Université Victor
Segalen, 146 rue Léo Saignat, 33076 Bordeaux, France.
Before extending the application of motor cortex stimulation it is important to
investigate the intimate mechanisms by which it alleviates intractable pain and
to consider possible side effects. Self-mutilation in animals following extensive
neurectomy or posterior rhizotomy of a limb is thought to reveal severe
dysesthesias in the deafferented zone suggesting its usefulness as an animal
model of chronic pain in humans. We here show in deafferented nonhuman primates
that the autotomy behavior immediately follows the surgery and disappears after
28 days. In keeping with the experience of Y. Lamarre, the simple but careful
care of all wounds is sufficient to abolish this behavior. Our results do not
exclude the possibility that the deafferentiation is still painful for the
monkeys, but they definitely rule out that autotomy is a consistent response to
deafferentation.
DOI: 10.1179/016164103101201274
PMID: 12635510 [Indexed for MEDLINE]