Tasks for inhibitory interneurons in intact brain circuits.

1. Neuropharmacology. 2015 Jan;88:10-23. doi: 10.1016/j.neuropharm.2014.09.011. Epub
2014 Sep 17.

Tasks for inhibitory interneurons in intact brain circuits.

Roux L(1), Buzsáki G(2).

Author information:
(1)NYU Neuroscience Institute, School of Medicine and Center for Neural Science,
New York University, New York, NY 10016, USA.
(2)NYU Neuroscience Institute, School of Medicine and Center for Neural Science,
New York University, New York, NY 10016, USA. Electronic address:
.

Synaptic inhibition, brought about by a rich variety of interneuron types,
counters excitation, modulates the gain, timing, tuning, bursting properties of
principal cell firing, and exerts selective filtering of synaptic excitation. At
the network level, it allows for coordinating transient interactions among the
principal cells to form cooperative assemblies for efficient transmission of
information and routing of excitatory activity across networks, typically in the
form of brain oscillations. Recent techniques based on targeted expression of
neuronal activity modulators, such as optogenetics, allow physiological
identification and perturbation of specific interneuron subtypes in the intact
brain. Combined with large-scale recordings or imaging techniques, these
approaches facilitate our understanding of the multiple roles of inhibitory
interneurons in shaping circuit functions.

Copyright © 2014 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neuropharm.2014.09.011
PMCID: PMC4254329
PMID: 25239808 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus