Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
Sci Rep. 2012-02-09; 2(1):
DOI: 10.1038/srep00253
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1. Sci Rep. 2012;2:253. doi: 10.1038/srep00253. Epub 2012 Feb 9.
Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
Dehay B(1), Dalkara D, Dovero S, Li Q, Bezard E.
Author information:
(1)Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000
Bordeaux, France.
Transgenic macaques would allow to study brain function and diseases. We report
that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected
intravenously in newborn rhesus macaques results in efficient,
exclusively-neuronal and widespread transduction of the brain. The present data
pave the way to large-scale genetic modelling of brain diseases in the rhesus
macaque.
DOI: 10.1038/srep00253
PMCID: PMC3275921
PMID: 22355765 [Indexed for MEDLINE]