Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.

Seil Jang, Daeyoung Oh, Yeunkum Lee, Eric Hosy, Hyewon Shin, Christoph van Riesen, Daniel Whitcomb, Julia M Warburton, Jihoon Jo, Doyoun Kim, Sun Gyun Kim, Seung Min Um, Seok-kyu Kwon, Myoung-Hwan Kim, Junyeop Daniel Roh, Jooyeon Woo, Heejung Jun, Dongmin Lee, Won Mah, Hyun Kim, Bong-Kiun Kaang, Kwangwook Cho, Jeong-Seop Rhee, Daniel Choquet, Eunjoon Kim
Nat Neurosci. 2015-11-23; 19(1): 84-93
DOI: 10.1038/nn.4176

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1. Nat Neurosci. 2016 Jan;19(1):84-93. doi: 10.1038/nn.4176. Epub 2015 Nov 23.

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.

Jang S(#)(1), Oh D(#)(2)(3), Lee Y(#)(4), Hosy E(#)(5), Shin H(2), van Riesen
C(6), Whitcomb D(7)(8), Warburton JM(7), Jo J(7)(9), Kim D(4), Kim SG(4), Um
SM(1), Kwon SK(1), Kim MH(10)(11), Roh JD(4), Woo J(1), Jun H(12), Lee D(13), Mah
W(14), Kim H(13), Kaang BK(12), Cho K(7)(8), Rhee JS(6), Choquet D(5), Kim

Author information:
(1)Department of Biological Sciences, Korea Advanced Institute of Science and
Technology (KAIST), Daejeon 305-701, Korea.
(2)Department of Biomedical Sciences, Korea Advanced Institute of Science and
Technology (KAIST), Daejeon 305-701, Korea.
(3)Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seoul,
(4)Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS),
Daejeon 305-701, Korea.
(5)University of Bordeaux, Interdisciplinary Institute for Neuroscience, France;
CNRS UMR 5297, F-33000 Bordeaux, France.
(6)Department of Molecular Neurobiology, Max Planck Institute of Experimental
Medicine, D-37075 Göttingen, Germany.
(7)School of Clinical Sciences, Faculty of Medicine and Dentistry, University of
Bristol, Whitson street, Bristol, UK.
(8)Centre for Synaptic Plasticity, University of Bristol, Whitson street,
Bristol, UK.
(9)Department of Biomedical Sciences, Chonnam National University Medical School,
Gwangju, South Korea.
(10)Department of Physiology, Seoul National University College of Medicine,
Seoul 110-799, Republic of Korea.
(11)Seoul National University Bundang Hospital, Seongnam, Gyeonggi 463-707,
Republic of Korea.
(12)Brain and Cognitive Sciences, College of Natural Sciences, Seoul National
University, Seoul 151-747, Korea.
(13)Department of Anatomy and Division of Brain Korea 21 Biomedical Science,
College of Medicine, Korea University, 126-1, 5-Ka, Anam-Dong, Seongbuk-Gu, Seoul
136-705, Korea.
(14)Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook
National University, Daegu 700-412, Korea.
(#)Contributed equally

Synaptic adhesion molecules regulate synapse development and plasticity through
mechanisms that include trans-synaptic adhesion and recruitment of diverse
synaptic proteins. We found that the immunoglobulin superfamily member 11
(IgSF11), a homophilic adhesion molecule that preferentially expressed in the
brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95
and AMPA glutamate receptors (AMPARs). IgSF11 required PSD-95 binding for its
excitatory synaptic localization. In addition, IgSF11 stabilized synaptic AMPARs,
as determined by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic
transmission and increased surface mobility of AMPARs, measured by
high-throughput, single-molecule tracking. IgSF11 deletion in mice led to the
suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and
long-term potentiation in the CA1 region of the hippocampus. IgSF11 did not
regulate the functional characteristics of AMPARs, including desensitization,
deactivation or recovery. These results suggest that IgSF11 regulates excitatory
synaptic transmission and plasticity through its tripartite interactions with
PSD-95 and AMPARs.

DOI: 10.1038/nn.4176
PMCID: PMC5010778
PMID: 26595655 [Indexed for MEDLINE]

Conflict of interest statement: Competing interest declaration The authors
declare that they have no competing financial interests.

Auteurs Bordeaux Neurocampus