Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations

Chloé Boitard, Shauna L. Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
Front. Behav. Neurosci.. 2016-11-21; 10:
DOI: 10.3389/fnbeh.2016.00225

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1. Front Behav Neurosci. 2016 Nov 21;10:225. eCollection 2016.

Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive
Alterations.

Boitard C(1), Parkes SL(2), Cavaroc A(1), Tantot F(1), Castanon N(1), Layé S(1),
Tronel S(3), Pacheco-Lopez G(4), Coutureau E(5), Ferreira G(1).

Author information:
(1)Institut national de la Recherche Agronomique (INRA), Nutrition and
Integrative Neurobiology, UMR 1286Bordeaux, France; Université de
BordeauxBordeaux, France.
(2)Institut national de la Recherche Agronomique (INRA), Nutrition and
Integrative Neurobiology, UMR 1286Bordeaux, France; Université de
BordeauxBordeaux, France; Centre National de la Recherche Scientifique (CNRS),
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287Bordeaux, France.
(3)Université de BordeauxBordeaux, France; Institut National de la Santé et de la
Recherche Médicale (INSERM), U1215 Neuro Centre MagendieBordeaux, France.
(4)Biological and Health Sciences Division, Campus Lerma, Metropolitan Autonomous
University (UAM) Lerma, Mexico.
(5)Université de BordeauxBordeaux, France; Centre National de la Recherche
Scientifique (CNRS), Institut de Neurosciences Cognitives et Intégratives
d’Aquitaine, UMR 5287Bordeaux, France.

In addition to metabolic and cardiovascular disorders, obesity is associated with
adverse cognitive and emotional outcomes. Its growing prevalence in adolescents
is particularly alarming since this is a period of ongoing maturation for brain
structures (including the hippocampus and amygdala) and for the
hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive
and emotional processing. We recently demonstrated that adolescent, but not
adult, high-fat diet (HF) exposure leads to impaired hippocampal function and
enhanced amygdala function through HPA axis alteration (Boitard et al., 2012,
2014, 2015). Here, we assessed whether the effects of adolescent HF consumption
on brain function are permanent or reversible. After adolescent exposure to HF,
switching to a standard control diet restored levels of hippocampal neurogenesis
and normalized enhanced HPA axis reactivity, amygdala activity and avoidance
memory. Therefore, while the adolescent period is highly vulnerable to the
deleterious effects of diet-induced obesity, adult exposure to a standard diet
appears sufficient to reverse alterations of brain function.

DOI: 10.3389/fnbeh.2016.00225
PMCID: PMC5116459
PMID: 27917115


Auteurs Bordeaux Neurocampus