Surface mobility of postsynaptic AMPARs tunes synaptic transmission

M. Heine, L. Groc, R. Frischknecht, J.-C. Bei que, B. Lounis, G. Rumbaugh, R. L. Huganir, L. Cognet, D. Choquet
Science. 2008-04-11; 320(5873): 201-205
DOI: 10.1126/science.1152089

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1. Science. 2008 Apr 11;320(5873):201-5. doi: 10.1126/science.1152089.

Surface mobility of postsynaptic AMPARs tunes synaptic transmission.

Heine M(1), Groc L, Frischknecht R, Béïque JC, Lounis B, Rumbaugh G, Huganir RL,
Cognet L, Choquet D.

Author information:
(1)CNRS, UMR 5091, Université Bordeaux, Bordeaux, France.

Comment in
Science. 2008 Apr 11;320(5873):183-4.

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission.
Upon fast consecutive synaptic stimulation, transmission can be depressed.
Recuperation from fast synaptic depression has been attributed solely to recovery
of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral
diffusion, observed in both intact hippocampi and cultured neurons, allows fast
exchange of desensitized receptors with naïve functional ones within or near the
postsynaptic density. Recovery from depression in the tens of millisecond time
range can be explained in part by this fast receptor exchange. Preventing AMPAR
surface movements through cross-linking, endogenous clustering, or calcium rise
all slow recovery from depression. Physiological regulation of postsynaptic
receptor mobility affects the fidelity of synaptic transmission by shaping the
frequency dependence of synaptic responses.

DOI: 10.1126/science.1152089
PMCID: PMC2715948
PMID: 18403705 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus