Surface-Based Morphometry of Cortical Thickness and Surface Area Associated with Heschl’s Gyri Duplications in 430 Healthy Volunteers.
Front. Hum. Neurosci.. 2016-03-07; 10:
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1. Front Hum Neurosci. 2016 Mar 7;10:69. doi: 10.3389/fnhum.2016.00069. eCollection
Surface-Based Morphometry of Cortical Thickness and Surface Area Associated with
Heschl’s Gyri Duplications in 430 Healthy Volunteers.
Marie D(1), Maingault S(1), Crivello F(1), Mazoyer B(1), Tzourio-Mazoyer N(1).
(1)Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives
UMR 5293, Université de BordeauxBordeaux, France; Centre National de la Recherche
Scientifique, Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies
Neurodégénératives UMR 5293Bordeaux, France; Commissariat à l’Énergie Atomique et
aux Énergies Alternatives, Groupe d’Imagerie Neurofonctionnelle, Institut des
Maladies Neurodégénératives UMR 5293Bordeaux, France.
We applied Surface-Based Morphometry to assess the variations in cortical
thickness (CT) and cortical surface area (CSA) in relation to the occurrence of
Heschl’s gyrus (HG) duplications in each hemisphere. 430 healthy brains that had
previously been classified as having a single HG, Common Stem Duplication (CSD)
or Complete Posterior Duplication (CPD) in each hemisphere were analyzed. To
optimally align the HG area across the different groups of gyrification, we
computed a specific surface-based template composed of 40 individuals with a
symmetrical HG gyrification pattern (20 single HG, 10 CPD, 10 CSD). After
normalizing the 430 participants’ T1 images to this specific template, we
separately compared the groups constituted of participants with a single HG, CPD,
and CSD in each hemisphere. The occurrence of a duplication in either hemisphere
was associated with an increase in CT posterior to the primary auditory cortex.
This may be the neural support of expertise or great abilities in either speech
or music processing domains that were related with duplications by previous
studies. A decrease in CSA in the planum temporale was detected in cases with
duplication in the left hemisphere. In the right hemisphere, a medial decrease in
CSA and a lateral increase in CSA were present in HG when a CPD occurred together
with an increase in CSA in the depth of the superior temporal sulcus (STS) in CSD
compared to a single HG. These variations associated with duplication might be
related to the functions that they process jointly within each hemisphere:
temporal and speech processing in the left and spectral and music processing in