Suicidal ideation in a European Huntington’s disease population.

Anna A.M. Hubers, Erik van Duijn, Raymund A.C. Roos, David Craufurd, Hugh Rickards, G. Bernhard Landwehrmeyer, Rose C. van der Mast, Erik J. Giltay
Journal of Affective Disorders. 2013-10-01; 151(1): 248-258
DOI: 10.1016/j.jad.2013.06.001

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1. J Affect Disord. 2013 Oct;151(1):248-58. doi: 10.1016/j.jad.2013.06.001. Epub
2013 Jul 20.

Suicidal ideation in a European Huntington’s disease population.

Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer
G, van der Mast RC, Giltay EJ; REGISTRY investigators of the European
Huntington’s Disease Network.

Collaborators: Bachoud-Lévi AC, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder
JM, Dunnett SB, Ferreira JJ, Handley OJ, Heiberg A, llmann TI, Landwehrmeyer GB,
Levey J, Ramos-Arroyo MA, Nielsen JE, ProKoivisto S, Päivärinta M, Roos RA, Rojo
Sebastián A, Tabrizi SJ, Vandenberghe W, Verellen- Dumoulin C, Zaremba J, Uhrova
T, Wahlström J, Barth K, Correia-Guedes L, Finisterra AM, Garde MB, Bos R, Betz
S, Callaghan J, Fullam R, Ecker D, Nielsen MG, Handley OJ, Hvalstedt C, Held C,
Koppers K, Laurà M, Horta SM, Descals AM, Mestre T, Minster S, Monza D, Mütze L,
Oehmen M, Townhill J, Orth M, Padieu H, Paterski L, Peppa N, Pro Koivisto S,
Roedig V, Rialland A, Røren N, Šašinková P, Seliverstov Y, Cubillo PT, Walsem MR,
Wright A, da Silva WV, Witjes-Ané MN, Yudina E, Zielonka D, Zielonka E, Zinzi P,
Bonelli RM, Herranhof B, Holl A, Kapfhammer HP, Koppitz M, Magnet M, Otti D,
Painold A, Reisinger K, Scheibl M, Hecht K, Lilek S, Müller N, Schöggl H, Ullah
J, Brugger F, Hepperger C, Hotter A, Seppi K, Wenning G, Buratti L, Hametner EM,
Holas C, Hametner EM, Hussl A, Poewe W, Braunwarth EM, Sprenger F, Müller C,
Lilek S, Sinadinosa D, Walleczek AM, Bonelli RM, Ladurner G, Staffen W, Flamez A,
Morez V, de Raedt S, Boogaerts A, Vandenberghe W, van Reijen D, Klempíř J,
Majerová V, Roth J, Hartikainen P, Hiivola H, Martikainen K, Tuuha K, Ignatius J,
Kärppä M, Åman J, Mustonen A, Kajula O, Santala M, Allain P, Guérid MA, Gohier B,
Olivier A, Prundean A, Scherer- Gagou C, Verny C, Bost M, Babiloni B, Debruxelles
S, Duché C, Goizet C, Lafoucrière D, Jameau L, Spampinato U, De Bruycker C,
Cabaret M, Carette AS, Defebvre L, Decorte E, Delval A, Delliaux M, Destee A,
Dujardin K, Peter M, Plomhouse L, Sablonnière B, Simonin C, Defebvre L, Lemaire
MH, Manouvrier S, Thibault-Tanchou S, Vuillaume I, Krystkowiak P, Duru C, Roussel
M, Wannepain S, Berrissoul H, Bellonet M, Courtin F, Mantaux B, Fasquel V,
Godefroy O, Azulay JP, Fluchère F, Delfini M, Eusebio A, Mundler L, Longato N,
Rudolf G, Steinmetz G, Tranchant C, Wagner C, Zimmermann M, Marcel C, Calvas F,
Pariente J, Démonet JF, Cheriet S, Kosinski CM, Milkereit E, Probst D, Reetz K,
Sass C, Schiefer J, Schlangen C, Werner CJ, Gelderblom H, Priller J, Prüß H,
Spruth EJ, Andrich J, Ellrichmann G, Hoffmann R, Kaminski B, Saft C, Stamm C,
Lange H, Bosredon C, Maass A, Schmidt S, Storch A, Wolz M, Kohl Z, Winkler J,
Capetian P, Lambeck J, Zucker B, Boelmans K, Ganos C, Goerendt I, Hidding U,
Lewerenz J, Münchau A, Orth M, Schmalfeld J, Stubbe L, Zittel S, Diercks G,
Dressler D, Gorzolla H, Schrader C, Tacik P, Heinicke W, Longinus B, Bürk K,
Möller JC, Rissling I, Mühlau M, Peinemann A, Städtler M, Weindl A, Winkelmann J,
Ziegler C, Bohlen S, Hölzner E, Lange H, Reilmann R, Sass C, Dose M, Leythaeuser
G, Marquard R, Raab T, Schrenk C, Schuierer M, Barth K, Buck A, Connemann J,
Ecker D, Eschenbach C, Held C, Landwehrmeyer B, Lezius F, Nepper S, Niess A, Orth
M, Schwenk D, Süßmuth S, Trautmann S, Weydt P, Cormio C, Sciruicchio V, Serpino
C, Tommaso M, Capellari S, Cortelli P, Gallassi R, Poda R, Rizzo G, Scaglione C,
Bertini E, Ghelli E, Ginestroni A, Massaro F, Mechi C, Paganini M, Piacentini S,
Pradella S, Romoli AM, Sorbi S, Abbruzzese G, di Poggio MB, Di Maria E, Ferrandes
G, Mandich P, Marchese R, Albanese A, Di Bella D, Di Donato S, Gellera C,
Genitrini S, Mariotti C, Monza D, Nanetti L, Paridi D, Soliveri P, Tomasello C,
De Michele G, Di Maio L, Salvatore E, Rinaldi C, Rossi F, Massarelli M, Roca A,
Ammendola S, Russo CV, Squitieri F, Elifani F, Maglione V, Di Pardo A, Alberti S,
Griguoli A, Amico E, Martino T, Petrollini M, Bentivoglio AR, Catalli C, Di
Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G,
Piano C, Chiara P, Quaranta D, Romano S, Soleti F, Spadaro M, Zinzi P, Rinaldi C,
Rossi F, Massarelli M, Roca A, Ammendola S, Russo CV, Squitieri F, Elifani F,
Maglione V, Alberti S, Griguoli A, Amico E, Martino T, Petrollini M, Bentivoglio
AR, Catalli C, Di Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T,
Jacopini G, Loria G, Piano C, Chiara P, Quaranta D, Romano S, Soleti F, Spadaro
M, Zinzi P, van Hout MS, van Vugt JP, Weert A, Bolwijn J, Dekker M, Leenders K,
Kremer HP, Bos R, Dumas EM, van den Bogaard SJ, Roos RA, ‘t Hart EP, van Duijn E,
Økland E, Hauge E, Tyvoll H, Heiberg A, Walsem MR, Frich J, Aaserud O, Wehus R,
Bjørgo K, Fannemel M, Gørvell P, Lorentzen E, Koivisto SP, Retterstøl L, Overland
T, Stokke B, Sando B, Dziadkiewicz A, Nowak M, Robowski P, Sitek E, Slawek J,
Soltan W, Szinwelski M, Blaszcyk M, Boczarska-Jedynak M, Ciach-Wysocka E,
Gorzkowska A, Jasinska-Myga B, Opala G, Kłodowska-Duda G, Stompel D,
Banaszkiewicz K, Boćwińska D, Szczudlik A, Rudzińska M, Wójcik M, Dec M, Krawczyk
M, Jaremek KB, Szczygieł E, Stenwak A, ielewska AW, Bryl A, Ciesielska A,
Klimberg A, Marcinkowski J, Sempołowicz J, Zielonka D, Samara H, Wiśniewski B,
Janik P, Gogol A, Kwiecinski H, Jamrozik Z, Kaminska A, Antczak J, Jachinska K,
Rakowicz M, Richter P, Rola R, Ryglewicz D, Sienkiewicz-Jarosz H, Stępniak I,
Witkowski G, Zdzienicka E, Zaremba J, Sułek A, Krysa W, Stępniak I,
Zieora-Jakutowicz K, Júlio F, Januário C, Mestre T, Correia-Guedes L, Coelho M,
Mendes T, Valadas A, Ferreira JJ, Timóteo Â, Costa C, Cavaco S, Damásio J,
Loureiro R, Magalhães M, Andrade C, Gago M, Garrett C, Guerra MR, Lima J, Massano
J, Meireles J, Herrera CD, Garcia PM, Barrero F, Morales B, Cubo E, Mariscal N,
Sánchez J, Alonso-Frech F, Perez MR, Fenollar M, García RG, Quiroga PP, Rivera
SV, Villanueva C, Alegre J, Bascuñana M, Caldentey JG, Ventura MF, Ribas GG,
Yébenes JG, López-Sendón Moreno JL, Cubillo PT, García Ruíz PJ, Martínez-Descals
A, Artiga MJ, Sánchez V, Guerrero R, Bárcenas AH, Noguera Perea MF, Fortuna L,
Martirio M, Torres A, Reinante G, Moreau LV, Barbera MA, Guia DB, Hernanz LC,
Catena JL, Sebastián AR, Ferrer PQ, Carruesco GT, Bas J, Busquets N, Calopa M,
Elorza MD, Díez-AjaLópez C, Terol SD, Robert MF, Ruíz BG, Casado AG, Martínez IH,
Viladrich CM, Càrdenas RP, Roca E, Llesoy JR, Idiago JM, Vergara MR, García SS,
Riballo AV, González SG, Guisasola LM, Salvador C, San Martín ES, González M,
Gorospe A, Legarda I, Arques PN, Torres Rodríguez MJ, Vives B, Gaston I,
Ramos-Arroyo MA, Martinez-Jaurrieta MD, Manuel J, Moreno G, Peña JC, Avarvarei
LD, Bastida AM, Recio MF, Vergé LR, Sánchez VS, Carrillo F, Cáceres MT, Mir P,
Suarez MJ, Bosca M, Burguera JA, Garcia AC, Brugada FC, Martínez LM, Val JL,
Loutfi G, Olofsson C, Stattin EL, Westman L, Wikström B, lhagen SE, Paucar M,
Svenningsson P, Reza- Soltani TW, Höglund A, Sandström B, Wahlström J,
Høsterey-Ugander U, Fredlund G, Constantinescu R, Neleborn-Lingefjärd L, Tedr-
off J, Esmaeilzadeh M, Winnberg E, Pålhagen S, Svennigsson P, Paucar M,
Riza-Soltani TW, Sundblom J, Johansson A, Wiklund L, Ekwall C, Göller ML,
Petersén A, Reimer J, Widner H, Burgunder JM, Stebler Y, Kaelin A, Romero I,
Schüpbach M, Weber S, Miedzybrodzka Z, Rae D, Downie L, Simpson S, Summers F, Ure
A, Jack R, Matheson K, Akhtar S, Crooks J, Curtis A, Souza J, Rickards H, Wright
J, Hayward B, Sieradzan K, Wright A, Barker RA, O’Keefe D, Di Pietro A, Fisher K,
Hill S, Mason S, Swain R, Valle N, Guzman, Bisson J, Busse M, Butcher C,
Callaghan J, Clenaghan C, Dunnett S, Fullam R, Handley O, Hunt S, Hughes A,
Johnstone C, Jones L, Jones U, Khalil H, Minster S, Owen M, Price K, Rose LE,
Townhill J, Rosser A, Porteous M, Edwards M, Ho C, McGill M, Pearson P, Brockie
P, Foster J, Johns N, McKenzie S, Rothery J, Thomas G, Yates S, Miller J, Ritchie
S, Burrows L, Fletcher A, Harding A, Laver F, Silva M, Thomson A, Rowett L,
Gallantrae D, Longthorpe M, Markova I, Raman A, Hamer S, Wild S, Yarduiman P, Chu
C, Kraus A, Wild S, Yardumian P, Musgrave H, Rowett L, Toscano J, Jamieson S,
Hobson E, Clayton C, Dipple H, Middleton J, Freire-Patino D, Andrews T, Dougherty
A, Kavalier F, Golding C, Laing H, Lashwood A, Robertson D, Ruddy D, Whaite A,
Santhouse A, Patton M, Peterson M, Rose S, Andrews T, Bruno S, Chu E, Doherty K,
Golding C, Haider S, Hensman D, Lahiri N, Lewis M, Novak M, Patel A, Robertson N,
Rosser E, Tabrizi S, Taylor R, Warner T, Wild E, Craufurd D, Fullam R, Howard L,
Sollom A, Snowden J, Thompson J, Callaghan J, Jones M, Murphy H, Trender-Gerhard
I, Rogers D, Bek J, Oughton E, Johnson L, Hare M, Arran N, Verstraelen N,
Partington-Jones L, Huson S, Stopford C, Westmoreland L, Davidson J, Morgan K,
Savage L, Singh B, Komati S, Nemeth AH, Armstrong R, Valentine R, Siuda G,
Harrison D, Hughes M, Parkinson A, Soltysiak B, Burn J, Coleman C, Bandmann O,
Bradbury A, Gill P, Fairtlough H, Fillingham K, Foustanos I, Kazoka M, O’Donovan
K, Peppa N, Taylor C, Tidswell K, Quarrell O.

BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation,
suicide attempts, and completed suicide in Huntington’s disease (HD) compared
with the general population. This study investigates correlates and predictors of
suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all
participating in the REGISTRY study of the European Huntington’s Disease Network.
Of the 1937 participants without suicidal ideation at baseline, 945 had one or
more follow-up measurements. Participants were assessed for suicidal ideation by
the behavioural subscale of the Unified Huntington’s Disease Rating Scale
(UHDRS). Correlates of suicidal ideation were analyzed using logistic regression
analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation.
Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0),
anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a
previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood
(OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at
baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%.
Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI:
1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were
independent predictors of incident suicidal ideation, whereas a previous suicide
attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants
were a selection of all HD mutation carriers, the prevalence of suicidal ideation
was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal
ideation is a priority in mutation carriers with a depressed mood and in those
using benzodiazepines.

© 2013 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.jad.2013.06.001
PMID: 23876196 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus