Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation

Rene Reese, Christine Winter, Agnes Nadjar, Daniel Harnack, Rudolf Morgenstern, Andreas Kupsch, Erwan Bezard, Wassilios Meissner
NeuroReport. 2008-01-01; 19(2): 179-182
DOI: 10.1097/WNR.0b013e3282f417b4

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1. Neuroreport. 2008 Jan 22;19(2):179-82. doi: 10.1097/WNR.0b013e3282f417b4.

Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation.

Reese R(1), Winter C, Nadjar A, Harnack D, Morgenstern R, Kupsch A, Bezard E,
Meissner W.

Author information:
(1)CNRS UMR 5227, Bordeaux, France.

Subthalamic stimulation enhances striatal tyrosine hydroxylase activity, which is
regulated by phosphorylation at different serine residues. Western blotting was
performed to investigate phosphorylation at the serine residues 19, 31 and 40 in
striatal tissue of rats that had received subthalamic stimulation or sham
stimulation for 2 h. In animals that were killed directly after stimulation, the
tyrosine hydroxylase protein content was unchanged, whereas phosphorylation at
the serine residue 19 was increased and phosphorylation at the serine residues 31
and 40 tended to be higher compared with controls. By contrast, tyrosine
hydroxylase protein content and phosphorylation were similar in rats that were
killed 24 h after stimulation. Our results suggest that subthalamic stimulation
may increase tyrosine hydroxylase activity via increased phosphorylation.

DOI: 10.1097/WNR.0b013e3282f417b4
PMID: 18185104 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus