Subjective cognitive and non‐cognitive complaints and brain MRI biomarkers in the MEMENTO cohort

Virginie Dauphinot, Vincent Bouteloup, Jean‐François Mangin, Bruno Vellas, Florence Pasquier, Frédéric Blanc, Olivier Hanon, Audrey Gabelle, Cédric Annweiler, Renaud David, Vincent Planche, Olivier Godefroy, Thérèse Rivasseau‐Jonveaux, Marie Chupin, Clara Fischer, Geneviève Chêne, Carole Dufouil, Pierre Krolak‐Salmon
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2020-01-01; 12(1):
DOI: 10.1002/dad2.12051

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Dauphinot V(1), Bouteloup V(2)(3), Mangin JF(4)(5), Vellas B(6)(7), Pasquier F(8), Blanc F(9), Hanon O(10), Gabelle A(11), Annweiler C(12)(13), David R(14), Planche V(15), Godefroy O(16)(17), Rivasseau-Jonveaux T(18)(19), Chupin M(4)(5), Fischer C(4)(5), Chêne G(2)(3), Dufouil C(2)(3), Krolak-Salmon P(1)(18)(19).

Author information:
(1)Clinical and Research Memory Centre of Lyon Lyon Institute for Elderly
Charpennes Hospital University Hospital of Lyon Lyon France.
(2)Inserm Bordeaux Population Health Research Center UMR 1219 Bordeaux University
ISPED Bordeaux University Bordeaux France.
(3)University hospital of Bordeaux Public Health Center Bordeaux France.
(4)CATI Multicenter Neuroimaging Platform (
Gif-sur-Yvette Paris France.
(5)Neurospin CEA Paris-Saclay University Gif-sur-Yvette France.
(6)Gérontopôle University hospital of Toulouse (CHU Toulouse) Toulouse France.
(7)Inserm UMR1027 University of Toulouse III Paul Sabatier Toulouse France.
(8)Univ Lille Inserm 1171, CHU Clinical and Research Memory Research Centre
(CMRR) of Distalz Lille France.
(9)Clinical and Memory Research Centre of Strasbourg (CMRR) University hostpital
of Strasbourg Geriatrics unit Geriatric Day Hospital Strasbourg France.
(10)Geriatry unit Paris Descartes University Broca hospital Paris France.
(11)Clinical and Research Memory center of Montpellier Department of Neurology
Gui de Chauliac Hospital University of Montpellier Montpellier France.
(12)Department of Geriatric Medicine Angers University Hospital Angers University
Memory Clinic; Research Center on Autonomy and Longevity; UPRES EA 4638
University of Angers Angers France.
(13)Robarts Research Institute Department of Medical Biophysics Schulich School
of Medicine and Dentistry the University of Western Ontario London Ontario
(14)Clinical and Research Memory Centre of Nice University hospital of Nice EA
COBTeK Côte d’Azur University Nice France.
(15)Clinical and Research Memory Centre of Bordeaux Clinical neurosciences centre
University hospital of Bordeaux F-33000 Bordeaux France et 2. Univ. Bordeaux CNRS
gérontopole Institute of Neurodegenerative Diseases Bordeaux France.
(16)Departments of Neurology Amiens University Hospital (CHU Amiens) and
Laboratory of Functional Neurosciences (EA 4559) Jules Verne University of
Picardie Amiens France.
(17)Institute of the Brain and Spinal Cord Inserm U1127,3 CNRS, UMR 7225 Sorbonne
University Paris France.
(18)Clinical and Research Memory Centre of Lorraine Hospital of Brabois
Cognitive-behavioral unit Paul Spillmann Centre CHRU de Nancy France.
(19)Communications Research Group Interpsy EA4432 Psychology University of
Lorraine Nancy France.

Introduction: Subjective cognitive complaints may be a signature of preclinical
stage Alzheimer’s disease. However, the link between subjective cognitive and
non-cognitive complaints and brain alterations remains unclear.
Methods: The relationship between cognitive and non-cognitive complaints and
brain biomarkers, measured by structural magnetic resonance imaging, was
investigated in 2056 participants of the MEMENTO cohort of outpatients, who were
dementia-free at baseline. We assessed whether the cognitive status at inclusion
or the presence of the apolipoprotein E gene variant (APOE) ε4 could modulate the
association between the intensity of complaints and brain lesions.
Results: Smaller hippocampal volume was associated with higher memory complaints
and discomfort in daily life. In APOE ε4 carriers, smaller whole-brain white
matter and gray matter volumes and gyrification indices in several regions of
interest of the parietal and temporal lobes, in the entorhinal and the
para-hippocampal gyrus, were associated with higher memory complaint score.
Conclusions: The intensity of subjective complaints in not only memory but
discomfort in daily life was associated with brain degeneration markers. The
presence of APOE ε4 modulated the relationships between subjective memory
complaints and brain alterations.

© 2020 The Authors. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease
Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer’s

DOI: 10.1002/dad2.12051
PMCID: PMC7335902
PMID: 32647745

Conflict of interest statement: The authors declare that they have no competing

Auteurs Bordeaux Neurocampus