Strain-specific development of the mossy fiber system in organotypic cultures of the mouse hippocampus

H. Schwegler, B. Heimrich, F. Keller, P. Renner, W.E. Crusio
Neuroscience Letters. 1988-04-01; 87(1-2): 7-10
DOI: 10.1016/0304-3940(88)90136-X

The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation of 3-4 weeks, similar strain-specific patterns became apparent in vitro, as visualized by a modified Timm staining. From this experiment we can conclude that a postnatal extrinsic influence cannot be the cause of the strain-specific hippocampal features.

Auteurs Bordeaux Neurocampus