Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
Journal of Neuroimmunology. 2008-08-01; 200(1-2): 90-99
DOI: 10.1016/j.jneuroim.2008.06.011
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1. J Neuroimmunol. 2008 Aug 30;200(1-2):90-9. doi: 10.1016/j.jneuroim.2008.06.011.
Epub 2008 Jul 23.
Spatio-temporal differences in the profile of murine brain expression of
proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to
peripheral lipopolysaccharide administration.
André C(1), O’Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N.
Author information:
(1)INRA, UMR 1286 PsyNuGen, Université Victor Ségalen Bordeaux 2, CNRS, UMR 5226,
IFR8, F-33076 Bordeaux, France.
The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase
(IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction
of depressive-like behavior by peripheral innate immune system stimulation are
still poorly understood. By monitoring how cytokines parallel IDO mRNA expression
in the brain in response to intraperitoneal lipopolysaccharide injection in mice,
we report a time-dependent induction of IDO expression in both the hippocampus
and hypothalamus that was associated with a specific structure-dependent
expression of proinflammatory cytokines, particularly interferon-gamma. This
study suggests that different mechanisms regulate the activation of IDO by
lipopolysaccharide in various brain structures.
DOI: 10.1016/j.jneuroim.2008.06.011
PMCID: PMC2571040
PMID: 18653240 [Indexed for MEDLINE]