Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses
Cell Reports. 2022-02-01; 38(6): 110347
DOI: 10.1016/j.celrep.2022.110347
Lire sur PubMed
Ravasenga T(1), Ruben M(1), Regio V(1), Polenghi A(1), Petrini EM(1), Barberis A(2).
Author information:
(1)Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
(2)Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. Electronic address:
.
The induction of synaptic plasticity at an individual dendritic glutamatergic
spine can affect neighboring spines. This local modulation generates dendritic
plasticity microdomains believed to expand the neuronal computational capacity.
Here, we investigate whether local modulation of plasticity can also occur
between glutamatergic synapses and adjacent GABAergic synapses. We find that the
induction of long-term potentiation at an individual glutamatergic spine causes
the depression of nearby GABAergic inhibitory synapses (within 3 μm), whereas
more distant ones are potentiated. Notably, L-type calcium channels and calpain
are required for this plasticity spreading. Overall, our data support a model
whereby input-specific glutamatergic postsynaptic potentiation induces a
spatially regulated rearrangement of inhibitory synaptic strength in the
surrounding area through short-range heterosynaptic interactions. Such local
coordination of excitatory and inhibitory synaptic plasticity is expected to
influence dendritic information processing and integration.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement: Declaration of interests The authors declare no
competing interests.