Spatial learning depends on both the addition and removal of new hippocampal neurons.

David Dupret, Annabelle Fabre, Màtè Dàniel Döbrössy, Aude Panatier, José Julio Rodríguez, Stéphanie Lamarque, Valerie Lemaire, Stephane H. R Oliet, Pier-Vincenzo Piazza, Djoher Nora Abrous
PLoS Biol. 2007-08-07; 5(8): e214
DOI: 10.1371/journal.pbio.0050214

PubMed
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1. PLoS Biol. 2007 Aug;5(8):e214.

Spatial learning depends on both the addition and removal of new hippocampal
neurons.

Dupret D(1), Fabre A, Döbrössy MD, Panatier A, Rodríguez JJ, Lamarque S, Lemaire
V, Oliet SH, Piazza PV, Abrous DN.

Author information:
(1)INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France.

The role of adult hippocampal neurogenesis in spatial learning remains a matter
of debate. Here, we show that spatial learning modifies neurogenesis by inducing
a cascade of events that resembles the selective stabilization process
characterizing development. Learning promotes survival of relatively mature
neurons, apoptosis of more immature cells, and finally, proliferation of neural
precursors. These are three interrelated events mediating learning. Thus,
blocking apoptosis impairs memory and inhibits learning-induced cell survival and
cell proliferation. In conclusion, during learning, similar to the selective
stabilization process, neuronal networks are sculpted by a tightly regulated
selection and suppression of different populations of newly born neurons.

DOI: 10.1371/journal.pbio.0050214
PMCID: PMC1939885
PMID: 17683201 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus