Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus
The FASEB Journal. 2003-12-01; 17(15): 2337-2338
DOI: 10.1096/fj.03-0291fje
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1. FASEB J. 2003 Dec;17(15):2337-8. Epub 2003 Oct 2.
Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.
Bezard E(1), Baufreton J, Owens G, Crossman AR, Dudek H, Taupignon A, Brotchie
JM.
Author information:
(1)Basal Gang and CNRS UMR 5543, Université Victor Segalen, 33076 Bordeaux Cedex,
France.
It is well established that members of the hedgehog family are involved in tissue
patterning during development. We herein show that sonic hedgehog signaling
molecules are differentially regulated by dopamine depletion in the basal ganglia
of adult animals and specifically that sonic hedgehog levels are reduced in an
animal model of Parkinson’s disease. In addition, we show that sonic hedgehog
protein inhibits electrical activity in the subthalamic nucleus, a key element of
basal ganglia, within minutes of application. As the subthalamic nucleus is
overactive in parkinsonism, we suggest that enhancement of sonic hedgehog
signaling in the subthalamic nucleus may be of therapeutic value in Parkinson’s
disease.
DOI: 10.1096/fj.03-0291fje
PMID: 14525941 [Indexed for MEDLINE]