Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019-08-01; 94: 109654
DOI: 10.1016/j.pnpbp.2019.109654
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1. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109654. doi:
10.1016/j.pnpbp.2019.109654. Epub 2019 May 21.
Sexual dysfunctions are associated with major depression, chronic inflammation
and anticholinergic consumption in the real-world schizophrenia FACE-SZ national
cohort.
Fond G(1), Godin O(2), Dumontaud M(3), Faget C(3), Schürhoff F(4), Berna F(5),
Aouizerate B(6), Capdevielle D(7), Chereau I(8), D’Amato T(9), Dubertret C(10),
Dubreucq J(11), Leignier S(11), Mallet J(10), Misdrahi D(12), Passerieux C(13),
Rey R(9), Schandrin A(7), Szoke A(4), Urbach M(13), Vidailhet P(14), Leboyer
M(4), Lançon C(3), Boyer L(3), Llorca PM(8); FACE-SZ (FondaMental Academic
Centers of Expertise for Schizophrenia) group.
Author information:
(1)Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de
Médecine – Secteur Timone, EA 3279: CEReSS -Centre d’Etude et de Recherche sur
les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005
Marseille, France. Electronic address: .
(2)Fondation FondaMental, Créteil, France; Institut Pierre Louis d’Epidémiologie
et de Santé Publique, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136,
F-75013 Paris, France; INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie
et de Santé Publique, F-75013 Paris, France.
(3)Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de
Médecine – Secteur Timone, EA 3279: CEReSS -Centre d’Etude et de Recherche sur
les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005
Marseille, France.
(4)Fondation FondaMental, Créteil, France; INSERM U955, Équipe de Psychiatrie
Translationnelle, Créteil, France; DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux
Universitaires H Mondor, Université Paris-Est Créteil, Créteil, France.
(5)Fondation FondaMental, Créteil, France; Hôpitaux Universitaires de
Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine
Translationnelle de Strasbourg, Strasbourg, France.
(6)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
Université de Bordeaux, F-33076 Bordeaux, France; INRA, NutriNeuro, University
of Bordeaux, U1286, F-33076 Bordeaux, France.
(7)Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie
Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1,
Inserm 1061, Montpellier, France.
(8)Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de
Médecine, Université d’Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.
(9)Fondation FondaMental, Créteil, France; INSERM U1028, CNRS UMR5292, Centre de
Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe
PSYR2, Centre Hospitalier Le Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678
Bron Cedex, France.
(10)Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry,
Louis Mourier Hospital, Colombes, France; Inserm U894, Université Paris Diderot,
Sorbonne Paris Cité, Faculté de médecine, France.
(11)Fondation FondaMental, Créteil, France; Centre Référent de Réhabilitation
Psychosociale, CH Alpes Isère, Grenoble, France.
(12)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
Université de Bordeaux, F-33076 Bordeaux, France; CNRS UMR 5287-INCIA, F-33076
Bordeaux, France.
(13)Fondation FondaMental, Créteil, France; Centre Hospitalier de Versailles,
Service de psychiatrie et d’addictologie adulte, Le Chesnay, EA 4047 HANDIReSP,
UFR des Sciences de la Santé Simone Veil, Université Versailles
Saint-Quentin-en-Yvelines, Versailles, France.
(14)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
BACKGROUND: Sexual dysfunctions (SD) are frequent in schizophrenia (SZ) and
associated with treatment withdrawal, however they remain under-explored and
under-treated. To date, most of the studies have focused on SD as
antipsychotics’ side effects in therapeutic trials.
AIMS: The objectives of the present study were to determine the SD prevalence in
stabilized SZ outpatients and their clinical, pharmacological and biological
correlates.
METHOD: Two hundred and thirty-seven participants (61.2% men) were consecutively
included and received a thorough 2 days- clinical assessment including the
self-reported Sexual Functioning Questionnaire (SFQ). SD was defined by a SFQ
score ≥ 8.
RESULTS: Two hundred and thirty-seven subjects were recruited in the FACE-SZ
cohort, 41% of them reported sexual dysfunctions. In multivariate analyses, SD
have been associated with current major depressive disorder (adjusted odd ratio
aOR = 2.29[1.08-4.85], p = .03), anticholinergic prescription (aOR = 2.65,
p = .02) and chronic low-grade inflammation (aOR = 2.09, p = .03) independently
of age, gender, current cannabis use disorder and olanzapine prescription. No
antipsychotic has been associated with increased or decreased SD rate.
CONCLUSIONS: SD are frequent in SZ subjects. Major depression, anticholinergic
prescription and chronic low-grade peripheral inflammation may be the three
targets of interest for addressing this specific issue.
Copyright © 2019 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.pnpbp.2019.109654
PMID: 31125587 [Indexed for MEDLINE]