Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history
Stroke. 2009-04-23; 40(6): 2219-2221
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1. Stroke. 2009 Jun;40(6):2219-21. doi: 10.1161/STROKEAHA.108.540633. Epub 2009 Apr
Severe cerebral white matter hyperintensities predict severe cognitive decline in
patients with cerebrovascular disease history.
Dufouil C, Godin O, Chalmers J, Coskun O, MacMahon S, Tzourio-Mazoyer N, Bousser
MG, Anderson C, Mazoyer B, Tzourio C; PROGRESS MRI Substudy Investigators.
Collaborators: Brugeilles H, Lejeune P, Moreau C, Pasco A, Iglesias S, Viader F,
Constant JM, Courtheoux P, Jaillard A, Besson JM, Hommel M, Grand S, Lebas JF,
Lucas C, Leys D, Leclerc X, Pruvost JP, Neuville V, Rosolacci T, Ameri A, Chedru
F, Bérou P, Guillon B, Hinzelin G, Feve, Auffray E, Desal H, De Kersaint-Gilly,
Biousse V, Berthet K, Vahedi K, Bousser MG, Bousson V, Levy C, Brunereau L,
Tubiana J, Alamovitch S, Roullet E, De Broucker T, Gauthier N, Stroh-Marcy,
Dobbelaere P, Iba-Zizen MT, Cabanis S.
BACKGROUND AND PURPOSE: Cerebral white matter hyperintensities (WMHs) are
believed to be the consequence of small vessel disease, and it is uncertain
whether their extent predicts the risk of dementia in patients with vascular
disease history. Method- Brain MRI was performed in 226 participants of the
PROGRESS study. WMH severity was assessed using a visual rating scale. During
follow-up, patients were classified for incident severe cognitive deterioration
(including dementia) using standard criteria.
RESULTS: Over 4-year follow-up, the incidence of severe cognitive deterioration
ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or
severe WMHs at baseline. In multivariable analysis, incident severe cognitive
deterioration was associated with baseline severe WMHs (odds ratio=7.7, P