Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence
Progress in Brain Research. 2021-01-01; : 161-264
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1. Prog Brain Res. 2021;261:161-264. doi: 10.1016/bs.pbr.2021.02.001. Epub 2021 Mar
Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence.
De Deurwaerdère P(1), Chagraoui A(2), Di Giovanni G(3).
(1)Centre National de la Recherche Scientifique, Institut des Neurosciences
Intégratives et Cognitives d’Aquitaine, UMR 5287, Bordeaux, France. Electronic
(2)Laboratory of Neuronal and Neuroendocrine Differentiation and Communication,
Institute for Research and Innovation in Biomedicine of Normandy (IRIB),
Normandie University, UNIROUEN, INSERM U1239, Rouen, France; Department of
Medical Biochemistry, Rouen University Hospital, Rouen, France.
(3)Laboratory of Neurophysiology, Department of Physiology and Biochemistry,
Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Neuroscience
Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Electronic address: .
The interaction between serotonin (5-HT) and dopamine (DA) in the central nervous
system (CNS) plays an important role in the adaptive properties of living animals
to their environment. These are two modulatory, divergent systems shaping and
regulating in a widespread manner the activity of neurobiological networks and
their interaction. The concept of one interaction linking these two systems is
rather elusive when looking at the mechanisms triggered by these two systems
across the CNS. The great variety of their interacting mechanisms is in part due
to the diversity of their neuronal origin, the density of their fibers in a given
CNS region, the distinct expression of their numerous receptors in the CNS, the
heterogeneity of their intracellular signaling pathway that depend on the
cellular type expressing their receptors, and the state of activity of
neurobiological networks, conditioning the outcome of their mutual influences.
Thus, originally conceptualized as inhibition of 5-HT on DA neuron activity and
DA neurotransmission, this interaction is nowadays considered as a multifaceted,
mutual influence of these two systems in the regulation of CNS functions. These
new ways of understanding this interaction are of utmost importance to envision
the consequences of their dysfunctions underlined in several CNS diseases. It is
also essential to conceive the mechanism of action of psychotropic drugs directly
acting on their function including antipsychotic, antidepressant,
antiparkinsonian, and drug of abuse together with the development of therapeutic
strategies of Alzheimer’s diseases, epilepsy, obsessional compulsive disorders.
The 5-HT/DA interaction has a long history from the serendipitous discovery of
antidepressants and antipsychotics to the future, rationalized treatments of CNS
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PMID: 33785130 [Indexed for MEDLINE]