Sensory gating in adult with attention-deficit/hyperactivity disorder: Event-evoked potential and perceptual experience reports comparisons with schizophrenia
Biological Psychology. 2015-04-01; 107: 16-23
DOI: 10.1016/j.biopsycho.2015.03.002
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1. Biol Psychol. 2015 Apr;107:16-23. doi: 10.1016/j.biopsycho.2015.03.002. Epub 2015
Mar 9.
Sensory gating in adult with attention-deficit/hyperactivity disorder:
Event-evoked potential and perceptual experience reports comparisons with
schizophrenia.
Micoulaud-Franchi JA(1), Vaillant F(2), Lopez R(3), Peri P(2), Baillif A(2),
Brandejsky L(2), Steffen ML(4), Boyer L(5), Richieri R(5), Cermolacce M(4),
Bioulac S(6), Aramaki M(7), Philip P(8), Lancon C(5), Vion-Dury J(4).
Author information:
(1)Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie
Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille,
France; Services d’explorations fonctionnelles du système nerveux, Clinique du
sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR
CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France.
Electronic address: .
(2)Pôle de Psychiatrie « Solaris », Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France.
(3)Service de Neurologie, Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac
Montpellier, Montpellier, France; Inserm U1061, Montpellier F-34000 France.
(4)Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie
Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille,
France; Pôle de Psychiatrie « Solaris », Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille
Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3,
France.
(5)Pôle de Psychiatrie « Solaris », Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de santé publique évaluation des systèmes de soins et santé perçue,
Université de la Méditerranée-EA 3279-Faculté de Médecine, 27 bd Jean Moulin,
13385 Marseille Cedex 05, France.
(6)USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France;
Pôle Universitaire de Psychiatrie de l’Enfant et de l’Adolescent, Bordeaux,
France.
(7)Laboratoire de Mécanique et d’Acoustique, LMA, CNRS, UPR 7051, Aix-Marseille
Univ, Centrale Marseille, F-13402 Marseille Cedex 20, France.
(8)Services d’explorations fonctionnelles du système nerveux, Clinique du
sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR
CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France.
BACKGROUND: In daily life, adults with attention-deficit/hyperactivity disorder
(ADHD) report abnormal perceptual experiences that can be related to sensory
gating deficit. This study investigated and compared P50 suppression (a
neurophysiological measure of sensory gating) and perceptual abnormalities
related to sensory gating deficit in ADHD and schizophrenias patients.
METHODS: Three groups were compared: 24 adults with ADHD, 24 patients with
schizophrenia and 24 healthy subjects. The Sensory Gating Inventory (SGI), a
validated self-report questionnaire, was used to measure perceptual abnormalities
related to sensory gating deficit. P50 suppression was measured by P50 amplitude
changes in a dual-click conditioning-testing auditory event-related potential
procedure.
RESULTS: Adults with ADHD had significantly higher scores on the SGI and
significantly lower P50 suppression than healthy subjects. These deficits were
similar to those found in patients with schizophrenia. A correlation was found
between both the SGI and P50 suppression data in adults with ADHD and patients
with schizophrenia.
DISCUSSION: The findings confirm previous results found in patients with
schizophrenia. Moreover, adults with ADHD, similar to patients with
schizophrenia, had abnormal P50 suppression and reported being flooded with
sensory stimuli. Abnormal neurophysiologic responses to repetitive stimuli gave
rise to clinically abnormal perceptions.
Copyright © 2015 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.biopsycho.2015.03.002
PMID: 25766264 [Indexed for MEDLINE]