Selective involvement of the lateral entorhinal cortex in the control of the olfactory memory trace during conditioned odor aversion in the rat.
Behavioral Neuroscience. 2006-01-01; 120(5): 1180-1186
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1. Behav Neurosci. 2006 Oct;120(5):1180-6.
Selective involvement of the lateral entorhinal cortex in the control of the
olfactory memory trace during conditioned odor aversion in the rat.
Ferry B(1), Ferreira G, Traissard N, Majchrzak M.
(1)Laboratoire de Neurosciences Comportementales et Cognitives, FRE 2855 Centre
National de la Recherche Scientifique (CNRS)-Universite Louis Pasteur,
Evidence from the effect of aspiration lesions of the entorhinal cortex (EC) has
shown that this region is involved in conditioned odor-aversion (COA)
learning–that is, the avoidance of an odorized tasteless solution the ingestion
of which precedes toxicosis–by rendering COA tolerant to long odor-toxicosis
delay. The present study examined whether neurotoxic lesions restricted to the
lateral or medial parts of the EC, in comparison with large aspiration lesions,
were sufficient to produce this effect. Male Long-Evans rats received
odor-intoxication pairing with either a short (5-min) or long (120-min) delay
between the presentation of the odor and toxicosis. All groups, including
sham-lesioned controls, showed COA at the 5-min odor-toxicosis delay interval,
but only rats with lateral EC damage displayed COA at the longer delay. These
data show that the lateral EC is part of the substrate involved in the control of
the olfactory memory trace during COA.
PMID: 17014270 [Indexed for MEDLINE]