Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner.
Hippocampus. 2015-12-08; 26(3): 282-288
DOI: 10.1002/hipo.22551
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1. Hippocampus. 2016 Mar;26(3):282-8. doi: 10.1002/hipo.22551. Epub 2015 Dec 8.
Running per se stimulates the dendritic arbor of newborn dentate granule cells in
mouse hippocampus in a duration-dependent manner.
Dostes S(1)(2)(3), Dubreucq S(1)(3), Ladevèze E(2)(3), Marsicano G(1)(3), Abrous
DN(2)(3), Chaouloff F(1)(3), Koehl M(2)(3).
Author information:
(1)Endocannabinoids and NeuroAdaptation Group, Neurocentre Magendie, Bordeaux,
France.
(2)Neurogenesis and Physiopathology Group, NeuroCentre Magendie, Bordeaux,
France.
(3)Université Bordeaux Segalen, Bordeaux, France.
Laboratory rodents provided chronic unlimited access to running wheels display
increased neurogenesis in the hippocampal dentate gyrus. In addition, recent
studies indicate that such an access to wheels stimulates dendritic arborization
in newly formed neurons. However, (i) the presence of the running wheel in the
housing environment might also bear intrinsic influences on the number and shape
of new neurons and (ii) the dendritic arborization of new neurons might be
insensitive to moderate daily running activity (i.e., several hours). In keeping
with these uncertainties, we have examined neurogenesis and dendritic
arborization in newly formed granular cells in adult C57Bl/6N male mice housed
for 3 weeks under standard conditions, with a locked wheel, with a running wheel
set free 3 h/day, or with a running wheel set permanently free. The results
indicate that the presence of a blocked wheel in the home cage increased cell
proliferation, but not the number of new neurons while running increased in a
duration-dependent manner the number of newborn neurons, as assessed by DCX
labeling. Morphological analyses of the dendritic tree of newborn neurons, as
identified by BrdU-DCX co-staining, revealed that although the presence of the
wheel stimulated their dendritic architecture, the amplitude of this effect was
lower than that elicited by running activity, and was found to be running
duration-dependent.
© 2015 Wiley Periodicals, Inc.
DOI: 10.1002/hipo.22551
PMID: 26606164 [Indexed for MEDLINE]