Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis.

A. Tabarin, Y. Diz-Chaves, D. Consoli, M. Monsaingeon, T. L. Bale, M. D. Culler, R. Datta, F. Drago, W. W. Vale, G. F. Koob, E. P. Zorrilla, A. Contarino
European Journal of Neuroscience. 2007-10-17; 26(8): 2303-2314
DOI: 10.1111/j.1460-9568.2007.05856.x

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1. Eur J Neurosci. 2007 Oct;26(8):2303-14.

Role of the corticotropin-releasing factor receptor type 2 in the control of food
intake in mice: a meal pattern analysis.

Tabarin A(1), Diz-Chaves Y, Consoli D, Monsaingeon M, Bale TL, Culler MD, Datta
R, Drago F, Vale WW, Koob GF, Zorrilla EP, Contarino A.

Author information:
(1)EA 2975 Nutrition et Neurosciences, Universités Bordeaux 1, Victor Segalen
Bordeaux 2, Bordeaux, France.

The actions of corticotropin-releasing factor (CRF) and related peptides are
mediated by two receptors (CRF(1) and CRF(2)). The respective role of each
subtype in the control of food intake remains poorly known. In the present study,
we examined the quantity and microstructure of ingestive behavior of knockout
(KO) mice lacking CRF(2) receptors and their wild-type (WT) littermates. Under
basal conditions, CRF(2) KO mice showed increased nocturnal food intake, evident
as an increased zenith in circadian cosinor analysis of food intake.
Microstructure analysis revealed that this greater food intake reflected
increased meal size, rather than meal frequency, suggesting a decreased satiating
value of food. Following acute restraint stress, CRF(2) KO mice showed an intact
immediate anorectic response with increased latency to eat and decreased meal
size. However, CRF(2) deletion abolished the prolonged phase of restraint-induced
anorexia. CRF(2) KO mice did not differ from WT controls in feeding responses to
food deprivation or injection of ghrelin receptor agonists. Independent of
genotype, food deprivation increased food intake, with dramatic changes in meal
size, meal frequency, water : food ratio and eating rate. Acyl-ghrelin or
BIM-28131, a potent ghrelin analog, dose-dependently stimulated food intake by
increasing meal size (ghrelin, BIM-28131) and meal number (BIM-28131), while
slowing the average eating rate (BIM-28131) similarly in WT and KO mice. These
results suggest that the CRF(2) receptor is involved in the control of meal size
during the active phase of eating and following acute exposure to stress.

DOI: 10.1111/j.1460-9568.2007.05856.x
PMCID: PMC2741498
PMID: 17953621 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus