Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms.

Lucile Capuron, Nathalie Castanon
Inflammation-Associated Depression: Evidence, Mechanisms and Implications. 2016-01-01; : 31-44
DOI: 10.1007/7854_2016_14

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1. Curr Top Behav Neurosci. 2017;31:31-44. doi: 10.1007/7854_2016_14.

Role of Inflammation in the Development of Neuropsychiatric Symptom Domains:
Evidence and Mechanisms.

Capuron L(1)(2), Castanon N(3)(4).

Author information:
(1)Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286,
INRA, University Victor Segalen Bordeaux 2, 146 rue Léo Saignat, F-33076,
Bordeaux, France. .
(2)INRA, Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR
1286, University of Bordeaux, F-33076, Bordeaux, France.
.
(3)Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286,
INRA, University Victor Segalen Bordeaux 2, 146 rue Léo Saignat, F-33076,
Bordeaux, France.
(4)INRA, Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR
1286, University of Bordeaux, F-33076, Bordeaux, France.

The finding that inflammatory markers are elevated in various neuropsychiatric
disorders raises the need of identifying the precise research domain criteria
driven by inflammation. Based on the model of inflammation-induced depression it
has been possible to identify distinct pathophysiological pathways leading to
alterations in neurotransmitter metabolism with specific relevance for the
development of symptom constellations that are common to various neuropsychiatric
and neurodegenerative conditions. Moreover, converging data indicate that these
pathways interact with relevant vulnerability factors and modulatory systems to
ultimately impact the presentation of inflammation-driven neuropsychiatric
symptoms. Altogether, these findings make inflammation a key pivotal factor in
psychopathology. Developing treatments that target inflammation and modulate the
pathways and systems by which inflammatory processes selectively affect brain
function will be of particular relevance for the treatment of specific
neurobehavioral symptom domains.

DOI: 10.1007/7854_2016_14
PMID: 27221626 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus